| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Chk1 [2-280] |
|---|
| Ligand | BDBM14826 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | 33P-Radiometric_Method1 |
|---|
| Ki | 2.95±n/a nM |
|---|
| Citation |  D3R, DD Abbott CHK1 Kinase D3R D3R Publication Date 6/30/2015 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase Chk1 [2-280] |
|---|
| Name: | Serine/threonine-protein kinase Chk1 [2-280] |
|---|
| Synonyms: | CHEK1 | CHK1 | CHK1_HUMAN | CHK1_Kinase |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 32109.16 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O14757[2-280] |
|---|
| Residue: | 279 |
|---|
| Sequence: | AVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKM
LNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYL
HGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKR
REFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLAL
LHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTS
|
|
|
|---|
| BDBM14826 |
|---|
| n/a |
|---|
| Name | BDBM14826 |
|---|
| Synonyms: | 1-[5-chloro-2-(tetrahydrofuran-3-yloxy)phenyl]-3-(5-cyanopyrazin-2-yl)urea | 3-[5-chloro-2-(oxolan-3-yloxy)phenyl]-1-(5-cyanopyrazin-2-yl)urea | Chk1_12 | urea-based inhibitor 2a |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H14ClN5O3 |
|---|
| Mol. Mass. | 359.767 |
|---|
| SMILES | Clc1ccc(OC2CCOC2)c(NC(=O)Nc2cnc(cn2)C#N)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
