Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCHK1_Kinase
LigandBDBM14826
Substrate/Competitorn/a
Meas. Tech.33P-Radiometric_Method1
Ki 2.95±n/a nM
Citation D3R DD Abbott CHK1 Kinase D3R  221 Publication Date 6/30/2015
More Info.:Get all data from this article,  Assay Method
 
CHK1_Kinase
Name:CHK1_Kinase
Synonyms:n/a
Type:n/a
Mol. Mass.:32109.16
Organism:Homo sapiens (Human)
Description:n/a
Residue:279
Sequence:
AVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKM
LNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYL
HGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKR
REFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLAL
LHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM14826
n/a
NameBDBM14826
Synonyms:1-[5-chloro-2-(tetrahydrofuran-3-yloxy)phenyl]-3-(5-cyanopyrazin-2-yl)urea | 3-[5-chloro-2-(oxolan-3-yloxy)phenyl]-1-(5-cyanopyrazin-2-yl)urea | Chk1_12 | urea-based inhibitor 2a
TypeSmall organic molecule
Emp. Form.C16H14ClN5O3
Mol. Mass.359.767
SMILESClc1ccc(OC2CCOC2)c(NC(=O)Nc2cnc(cn2)C#N)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: