Ki Summary

Reaction Details

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Target

Serine/threonine-protein kinase Chk1 [2-280]

Ligand

BDBM225369

Substrate/Competitor

n/a

Meas. Tech.

33P-Radiometric_Method1

18.7±n/a nM

Citation

D3R, DD Abbott CHK1 Kinase D3R D3R Publication Date 6/30/2015

More Info.:

Get all data from this article, Assay Method

Serine/threonine-protein kinase Chk1 [2-280]

Name:

Serine/threonine-protein kinase Chk1 [2-280]

Synonyms:

CHEK1 | CHK1 | CHK1_HUMAN | CHK1_Kinase

Type:

n/a

Mol. Mass.:

32109.16

Organism:

Homo sapiens (Human)

Description:

O14757[2-280]

Residue:

279

Sequence:

AVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKM
LNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYL
HGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKR
REFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLAL
LHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTS

BDBM225369

n/a

Name

BDBM225369

Synonyms:

Chk1_118

Type

Small Organic Molecule

Emp. Form.

C30H29N3O4

Mol. Mass.

495.569

SMILES

COc1cc(ccc1O)-c1ccc(cc1)-c1[nH]nc-2c1Cc1cc(ccc-21)C(=O)NC1CCC(O)CC1 |(-6.97,-13.41,;-6.04,-12.19,;-6.64,-10.77,;-5.71,-9.54,;-6.31,-8.12,;-7.84,-7.93,;-8.77,-9.16,;-8.17,-10.58,;-9.1,-11.8,;-5.38,-6.89,;-5.98,-5.47,;-5.05,-4.25,;-3.52,-4.44,;-2.92,-5.86,;-3.85,-7.08,;-2.59,-3.21,;-3.04,-1.74,;-1.77,-.86,;-.55,-1.78,;-1.05,-3.24,;.18,-4.17,;1.44,-3.29,;2.94,-3.64,;3.99,-2.51,;3.55,-1.04,;2.05,-.69,;.99,-1.82,;5.49,-2.86,;5.94,-4.34,;6.55,-1.74,;8.05,-2.09,;9.1,-.97,;10.6,-1.32,;11.05,-2.79,;12.54,-3.14,;9.99,-3.91,;8.49,-3.56,)|

Structure