| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bile acid receptor |
|---|
| Ligand | BDBM225937 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Scintillation Proximity Assay (SPA) |
|---|
| pH | 7.4±n/a |
|---|
| IC50 | 1870±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  D3R, DD Drug Design Data Resource Grand Challenge 2 Dataset: FXR - Farnesoid X Receptor D3R D3R Publication Date 4/13/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bile acid receptor |
|---|
| Name: | Bile acid receptor |
|---|
| Synonyms: | BAR | Bile acid receptor FXR | FXR | Farnesol receptor HRR-1 | HRR1 | NR1H4 | NR1H4_HUMAN | Nuclear receptor subfamily 1 group H member 4 | RIP14 | RXR-interacting protein 14 | Retinoid X receptor-interacting protein 14 | farnesoid x receptor |
|---|
| Type: | Nuclear Receptor |
|---|
| Mol. Mass.: | 55916.24 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q96RI1 |
|---|
| Residue: | 486 |
|---|
| Sequence: | MVMQFQGLENPIQISPHCSCTPSGFFMEMMSMKPAKGVLTEQVAGPLGQNLEVEPYSQYS
NVQFPQVQPQISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTK
KPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCV
MDMYMRRKCQECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDSEG
RDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLI
LTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSD
LLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEK
LQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLC
EIWDVQ
|
|
|
|---|
| BDBM225937 |
|---|
| n/a |
|---|
| Name | BDBM225937 |
|---|
| Synonyms: | FXR_26 |
|---|
| Type | Small Organic Molecule |
|---|
| Emp. Form. | C29H32F2N6O |
|---|
| Mol. Mass. | 518.6008 |
|---|
| SMILES | Fc1cc2nc(-c3ccc(nc3)-n3cccn3)n([C@@H](C3CCCCC3)C(=O)NC3CCCCC3)c2cc1F |
|---|
| Structure | 
|
|---|
Search and Browse
