Ki Summary

Reaction Details

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Target

High affinity nerve growth factor receptor [441-796]

Ligand

BDBM226477

Substrate/Competitor

n/a

Meas. Tech.

Cell Based Assay

Temperature

310.15±n/a K

IC50

4.03±n/a nM

Comments

extracted

Citation

Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS Tropomyosin-related kinase inhibitors US Patent US9328096 Publication Date 5/3/2016

More Info.:

Get all data from this article, Assay Method

High affinity nerve growth factor receptor [441-796]

Name:

High affinity nerve growth factor receptor [441-796]

Synonyms:

Type:

Protein

Mol. Mass.:

39939.20

Organism:

Homo sapiens (Human)

Description:

Human his-tagged TrkA cytoplasmic domain (441-796 aa)

Residue:

356

Sequence:

KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDA
CVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQRE
AELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPG
PLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDY
YRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCI
TQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG

BDBM226477

n/a

Name

BDBM226477

Synonyms:

US9328096, 170

Type

Small organic molecule

Emp. Form.

C28H24Cl2FN5O3

Mol. Mass.

568.426

SMILES

O[C@H]1CC[C@@H](CC1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 |wU:4.7,wD:1.0,(.23,-5.74,;-1.3,-5.57,;-1.93,-4.17,;-3.46,-4.01,;-4.36,-5.25,;-3.74,-6.66,;-2.2,-6.82,;-5.89,-5.09,;-6.52,-3.69,;-8.05,-3.52,;-5.62,-2.44,;-4.08,-2.44,;-3.6,-.97,;-2.14,-.5,;-.99,-1.53,;-1.31,-3.04,;.47,-1.05,;1.62,-2.08,;3.08,-1.61,;3.4,-.1,;4.87,.37,;2.26,.93,;.79,.45,;-.35,1.48,;4.23,-2.64,;3.91,-4.14,;5.05,-5.18,;6.52,-4.7,;6.84,-3.19,;5.69,-2.16,;6.01,-.66,;-4.85,-.07,;-6.09,-.97,;-4.85,1.47,;-6.18,2.24,;-6.18,3.78,;-4.85,4.55,;-3.51,3.78,;-3.51,2.24,)|

Structure