Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetTyrosine kinase receptor A (TrkA)
LigandBDBM226729
Substrate/Competitorn/a
Meas. Tech.Cell Based Assay
Temperature310.15±n/a K
IC50 2.96±n/a nM
Commentsextracted
Citation Bagal SKCui JJGreasley SELunney EAMcAlpine IJNagata ANinkovic SOmoto KSkerratt SEStorer RIWarmus JS Tropomyosin-related kinase inhibitors US Patent  US9328096 Publication Date 5/3/2016
More Info.:Get all data from this article,  Assay Method
 
Tyrosine kinase receptor A (TrkA)
Name:Tyrosine kinase receptor A (TrkA)
Synonyms:NTRK1 | Tyrosine kinase receptor A
Type:Protein
Mol. Mass.:39939.20
Organism:Homo sapiens (Human)
Description:Human his-tagged TrkA cytoplasmic domain (441-796 aa)
Residue:356
Sequence:
KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDA
CVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQRE
AELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPG
PLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDY
YRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCI
TQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM226729
n/a
NameBDBM226729
Synonyms:US9328096, 422
TypeSmall organic molecule
Emp. Form.C29H26Cl2FN5O3
Mol. Mass.582.453
SMILESCC1(O)CCC(CC1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 |(-.04,-4.73,;-1.47,-5.31,;-.19,-6.17,;-2.1,-3.9,;-3.63,-3.74,;-4.53,-4.98,;-3.91,-6.39,;-2.38,-6.55,;-6.07,-4.82,;-6.69,-3.42,;-8.22,-3.25,;-5.79,-2.17,;-4.25,-2.17,;-3.77,-.71,;-2.31,-.23,;-1.16,-1.26,;-1.48,-2.77,;.3,-.78,;1.45,-1.81,;2.91,-1.34,;3.23,.17,;4.7,.64,;2.09,1.2,;.62,.72,;-.52,1.75,;4.06,-2.37,;5.52,-1.89,;6.67,-2.92,;6.34,-4.43,;7.49,-5.46,;4.88,-4.91,;3.74,-3.88,;-5.02,.2,;-6.26,-.71,;-5.02,1.74,;-6.35,2.51,;-6.35,4.05,;-5.02,4.82,;-3.68,4.05,;-3.68,2.51,)|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: