Ki Summary

Reaction Details

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Target

High affinity nerve growth factor receptor [441-796]

Ligand

BDBM226729

Substrate/Competitor

n/a

Meas. Tech.

Cell Based Assay

Temperature

310.15±n/a K

IC50

2.96±n/a nM

Comments

extracted

Citation

Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS Tropomyosin-related kinase inhibitors US Patent US9328096 Publication Date 5/3/2016

More Info.:

Get all data from this article, Assay Method

High affinity nerve growth factor receptor [441-796]

Name:

High affinity nerve growth factor receptor [441-796]

Synonyms:

Type:

Protein

Mol. Mass.:

39939.20

Organism:

Homo sapiens (Human)

Description:

Human his-tagged TrkA cytoplasmic domain (441-796 aa)

Residue:

356

Sequence:

KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDA
CVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQRE
AELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPG
PLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDY
YRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCI
TQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG

BDBM226729

n/a

Name

BDBM226729

Synonyms:

US9328096, 422

Type

Small organic molecule

Emp. Form.

C29H26Cl2FN5O3

Mol. Mass.

582.453

SMILES

CC1(O)CCC(CC1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 |(-.04,-4.73,;-1.47,-5.31,;-.19,-6.17,;-2.1,-3.9,;-3.63,-3.74,;-4.53,-4.98,;-3.91,-6.39,;-2.38,-6.55,;-6.07,-4.82,;-6.69,-3.42,;-8.22,-3.25,;-5.79,-2.17,;-4.25,-2.17,;-3.77,-.71,;-2.31,-.23,;-1.16,-1.26,;-1.48,-2.77,;.3,-.78,;1.45,-1.81,;2.91,-1.34,;3.23,.17,;4.7,.64,;2.09,1.2,;.62,.72,;-.52,1.75,;4.06,-2.37,;5.52,-1.89,;6.67,-2.92,;6.34,-4.43,;7.49,-5.46,;4.88,-4.91,;3.74,-3.88,;-5.02,.2,;-6.26,-.71,;-5.02,1.74,;-6.35,2.51,;-6.35,4.05,;-5.02,4.82,;-3.68,4.05,;-3.68,2.51,)|

Structure