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TargetTyrosine kinase receptor A (TrkA)
LigandBDBM226850
Substrate/Competitorn/a
Meas. Tech.Cell Based Assay
Temperature310.15±n/a K
IC50 4.69±n/a nM
Commentsextracted
Citation Bagal SKCui JJGreasley SELunney EAMcAlpine IJNagata ANinkovic SOmoto KSkerratt SEStorer RIWarmus JS Tropomyosin-related kinase inhibitors US Patent  US9328096 Publication Date 5/3/2016
More Info.:Get all data from this article,  Assay Method
 
Tyrosine kinase receptor A (TrkA)
Name:Tyrosine kinase receptor A (TrkA)
Synonyms:NTRK1 | Tyrosine kinase receptor A
Type:Protein
Mol. Mass.:39939.20
Organism:Homo sapiens (Human)
Description:Human his-tagged TrkA cytoplasmic domain (441-796 aa)
Residue:356
Sequence:
KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDA
CVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQRE
AELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPG
PLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDY
YRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCI
TQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG
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  Blast E-value cutoff:
BDBM226850
n/a
NameBDBM226850
Synonyms:US9328096, 543
TypeSmall organic molecule
Emp. Form.C26H20Cl2FN5O3
Mol. Mass.540.373
SMILESO[C@H]1C[C@@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 |wU:3.5,wD:1.0,(-5.13,-2.63,;-5.13,-1.09,;-4.04,-0,;-5.13,1.09,;-6.22,-0,;-5.13,2.63,;-3.8,3.4,;-3.8,4.94,;-2.46,2.63,;-2.3,1.09,;-.79,.77,;-.17,-.63,;-1.07,-1.88,;-2.6,-1.72,;-.45,-3.29,;-1.35,-4.53,;-.73,-5.94,;.81,-6.1,;1.43,-7.51,;1.71,-4.85,;1.08,-3.45,;1.99,-2.2,;-1.63,-7.18,;-3.16,-7.02,;-4.07,-8.27,;-3.44,-9.68,;-1.91,-9.84,;-1,-8.59,;.53,-8.75,;-.02,2.11,;-1.06,3.25,;1.51,2.27,;2.13,3.68,;3.66,3.84,;4.57,2.59,;3.94,1.18,;2.41,1.02,)|
Structure
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