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TargetTyrosine kinase receptor A (TrkA)
LigandBDBM226864
Substrate/Competitorn/a
Meas. Tech.Cell Based Assay
Temperature310.15±n/a K
IC50 1.02±n/a nM
Commentsextracted
Citation Bagal SKCui JJGreasley SELunney EAMcAlpine IJNagata ANinkovic SOmoto KSkerratt SEStorer RIWarmus JS Tropomyosin-related kinase inhibitors US Patent  US9328096 Publication Date 5/3/2016
More Info.:Get all data from this article,  Assay Method
 
Tyrosine kinase receptor A (TrkA)
Name:Tyrosine kinase receptor A (TrkA)
Synonyms:NTRK1 | Tyrosine kinase receptor A
Type:Protein
Mol. Mass.:39939.20
Organism:Homo sapiens (Human)
Description:Human his-tagged TrkA cytoplasmic domain (441-796 aa)
Residue:356
Sequence:
KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDA
CVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQRE
AELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPG
PLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDY
YRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCI
TQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG
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  Blast E-value cutoff:
BDBM226864
n/a
NameBDBM226864
Synonyms:US9328096, 557
TypeSmall organic molecule
Emp. Form.C28H20Cl2FN7O2
Mol. Mass.576.409
SMILESNc1cc(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)ccn1
Structure
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