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TargetButyrylcholinesterase (BChE)
LigandBDBM227585
Substrate/Competitorn/a
Meas. Tech.In Vitro AChE/BChE Inhibition Assay
pH7.4±n/a
Temperature298.15±n/a K
IC50 4.76±0.58 nM
Commentsextracted
Citation Czarnecka KSzymanski PGirek MMikiciuk-Olasik ESkibinski RKabzinski JMajsterek IMalawska BJonczyk JBajda M Tetrahydroacridine derivatives with fluorobenzoic acid moiety as multifunctional agents for Alzheimer's disease treatment. Bioorg Chem 72:315-322 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Butyrylcholinesterase (BChE)
Name:Butyrylcholinesterase
Synonyms:BuChE | Butyrlcholinesterase (BuChE) | Butyrylcholine esterase | Butyrylcholinesterase | Butyrylcholinesterase (BuChE) | Butyrylcholinesterase (EqBuChE) | Carboxylic ester hydrolase | butyrylcholinesterase precursor
Type:Protein
Mol. Mass.:68842.83
Organism:Equus caballus (Horse)
Description:Q9N1N9
Residue:602
Sequence:
MQSWGTIICIRILLRFLLLWVLIGNSHTEEDIIITTKNGKVRGMNLPVLGGTVTAFLGIP
YAQPPLGRLRFKKPQSLTKWSNIWNATKYANSCYQNTDQSFPGFLGSEMWNPNTELSEDC
LYLNVWIPAPKPKNATVMIWIYGGGFQTGTSSLPVYDGKFLARVERVIVVSMNYRVGALG
FLALSENPEAPGNMGLFDQQLALQWVQKNIAAFGGNPRSVTLFGESAGAASVSLHLLSPR
SQPLFTRAILQSGSSNAPWAVTSLYEARNRTLTLAKRMGCSRDNETEMIKCLRDKDPQEI
LLNEVFVVPYDTLLSVNFGPTVDGDFLTDMPDTLLQLGQFKRTQILVGVNKDEGTAFLVY
GAPGFSKDNNSIITRKEFQEGLKIFFPRVSEFGRESILFHYMDWLDDQRAENYREALDDV
VGDYNIICPALEFTKKFSELGNDAFFYYFEHRSTKLPWPEWMGVMHGYEIEFVFGLPLER
RVNYTKAEEILSRSIMKRWANFAKYGNPNGTQSNSTRWPVFKSTEQKYLTLNTESPKVYT
KLRAQQCRFWTLFFPKVLELTGNIDEAEREWKAGFHRWNNYMMDWKNQFNDYTSKKESCS
DF
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  Blast E-value cutoff:
BDBM227585
n/a
NameBDBM227585
Synonyms:3-Fluoro-N-[2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl]benzamide hydrochloride (3d)
TypeSmall organic molecule
Emp. Form.C22H22FN3O
Mol. Mass.363.428
SMILESFc1cccc(c1)C(=O)NCCNc1c2CCCCc2nc2ccccc12
Structure
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