Reaction Details |
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Target | Oxidized purine nucleoside triphosphate hydrolase |
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Ligand | BDBM227635 |
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Substrate/Competitor | BDBM227639 |
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Meas. Tech. | In Vitro MTH1 Enzymatic Assay |
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pH | 7.5±n/a |
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IC50 | 4.8e+3± 9e+2 nM |
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Comments | extracted |
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Citation | Kumar, A; Kawamura, T; Kawatani, M; Osada, H; Zhang, KYJ Identification and structure-activity relationship of purine derivatives as novel MTH1 inhibitors. Chem Biol Drug Des89:862-869 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Oxidized purine nucleoside triphosphate hydrolase |
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Name: | Oxidized purine nucleoside triphosphate hydrolase |
Synonyms: | 2-hydroxy-dATP diphosphatase | 3.6.1.- | 3.6.1.56 | 7,8-dihydro-8-oxoguanine triphosphatase | 8-oxo-dGTPase | 8ODP_HUMAN | MTH1 | Methylated purine nucleoside triphosphate hydrolase | MutT homolog 1 protein (MTH1) | NUDT1 | Nucleoside diphosphate-linked moiety X motif 1 | Nudix motif 1 | Oxidized purine nucleoside triphosphate hydrolase [42-197] |
Type: | Protein |
Mol. Mass.: | 22514.81 |
Organism: | Homo sapiens (Human) |
Description: | P36639 |
Residue: | 156 |
Sequence: | MGASRLYTLVLVLQPQRVLLGMKKRGFGAGRWNGFGGKVQEGETIEDGARRELQEESGLT
VDALHKVGQIVFEFVGEPELMDVHVFCTDSIQGTPVESDEMRPCWFQLDQIPFKDMWPDD
SYWFPLLLQKKKFHGYFKFQGQDTILDYTLREVDTV
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BDBM227635 |
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BDBM227639 |
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Name | BDBM227635 |
Synonyms: | MTH1 inhibitor, 122 |
Type | Small organic molecule |
Emp. Form. | C8H12N6O |
Mol. Mass. | 208.2205 |
SMILES | COCCNc1nc(N)nc2[nH]cnc12 |
Structure |
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