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TargetBromodomain-containing protein 4 [44-166,I246A]
LigandBDBM50365262
Substrate/Competitorn/a
Meas. Tech.Thermal Shift Assay (TSA)
pH7.5±n/a
Kd 2.4±0.0 nM
Commentsextracted
Citation Jung, MPhilpott, MMüller, SSchulze, JBadock, VEberspächer, UMoosmayer, DBader, BSchmees, NFernández-Montalván, AHaendler, B Affinity map of bromodomain protein 4 (BRD4) interactions with the histone H4 tail and the small molecule inhibitor JQ1. J Biol Chem289:9304-19 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Bromodomain-containing protein 4 [44-166,I246A]
Name:Bromodomain-containing protein 4 [44-166,I246A]
Synonyms:BRD4 | BRD4_HUMAN | Bromodomain protein 4 bromodomain 1 (BRD4 BD1 I146A) | HUNK1
Type:Protein
Mol. Mass.:14568.20
Organism:Homo sapiens (Human)
Description:Human BRD4 BD1 (44-166 aa) I146A mutant
Residue:123
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKT
PMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDAVLMAEALEKLFLQKINE
LPT
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  Blast E-value cutoff:
BDBM50365262
n/a
NameBDBM50365262
Synonyms:(+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10124009, Compound (S)-JQ1 | US10202360, Example JQ-1 | US10308662, Compound JQ-1 | US10407441, Compound (S)-JQ1 | US10617680, Example JQ-1 | US10881668, Compound JQ1 | US10925881, Name (S)-JQ1 | US11020380, Example JQ-1 | US11078188, Example (+)-JQ1 | US11279703, TABLE 6.180 | US11427593, Compound JQ1 | US11466034, Example (+)-JQ1 | US9320741, (S)-JQ1 | US9695172, JQ1
TypeSmall organic molecule
Emp. Form.C23H25ClN4O2S
Mol. Mass.456.988
SMILESCc1nnc2[C@H](CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |r,c:14|
Structure
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