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TargetBeta-glucuronidase
LigandBDBM229595
Substrate/Competitorn/a
Meas. Tech.Cell-Based Assay
EC50 3.41±1.13 nM
Citation Redinbo, MR Selective β-glucuronidase inhibitors as a treatment for side effects of camptothecin antineoplastic agents US Patent US9334288 Publication Date 5/10/2016
More Info.:Get all data from this article,  Assay Method
 
Beta-glucuronidase
Name:Beta-glucuronidase
Synonyms:β-Glucuronidase | BGLR_HUMAN | Beta-G1 | Beta-glucuronidase | GUSB | beta-Glucuronidase (β-glucuronidase)
Type:Protein
Mol. Mass.:74736.05
Organism:Homo sapiens (Human)
Description:n/a
Residue:651
Sequence:
MARGSAVAWAALGPLLWGCALGLQGGMLYPQESPSRECKELDGLWSFRADFSDNRRRGFE
EQWYRRPLWESGPTVDMPVPSSFNDISQDWRLRHFVGWVWYEREVILPERWTQDLRTRVV
LRIGSAHSYAIVWVNGVDTLEHEGGYLPFEADISNLVQVGPLPSRLRITIAINNTLTPTT
LPPGTIQYLTDTSKYPKGYFVQNTYFDFFNYAGLQRSVLLYTTPTTYIDDITVTTSVEQD
SGLVNYQISVKGSNLFKLEVRLLDAENKVVANGTGTQGQLKVPGVSLWWPYLMHERPAYL
YSLEVQLTAQTSLGPVSDFYTLPVGIRTVAVTKSQFLINGKPFYFHGVNKHEDADIRGKG
FDWPLLVKDFNLLRWLGANAFRTSHYPYAEEVMQMCDRYGIVVIDECPGVGLALPQFFNN
VSLHHHMQVMEEVVRRDKNHPAVVMWSVANEPASHLESAGYYLKMVIAHTKSLDPSRPVT
FVSNSNYAADKGAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSE
YGAETIAGFHQDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTR
VLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSVAKSQCLENSLFT
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  Blast E-value cutoff:
BDBM229595
n/a
NameBDBM229595
Synonyms:US9334288, 9
TypeSmall organic molecule
Emp. Form.C20H25N7OS
Mol. Mass.411.524
SMILESC1CCc2c(C1)c(nc1sc3c(nnnc3c21)N1CCNCC1)N1CCOCC1
Structure
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