| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase receptor R3 |
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| Ligand | BDBM118134 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ALK1-6 enzymatic assays |
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| pH | 7.5±n/a |
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| IC50 | 27±n/a nM |
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| Comments | extracted |
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| Citation |  Alimardanov, A; Cuny, GD; Grewal, GS; Lee, A; McKew, JC; Mohedas, AH; Shen, M; Xu, X; Yu, PB BMP inhibitors and methods of use thereof US Patent US9682983 Publication Date 6/20/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase receptor R3 |
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| Name: | Serine/threonine-protein kinase receptor R3 |
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| Synonyms: | ACVL1_HUMAN | ACVRL1 | ACVRLK1 | ALK1 | Activin receptor-like kinase 1 (ALK-1) | Serine/threonine-protein kinase receptor R3 (ALK1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 56134.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P37023 |
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| Residue: | 503 |
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| Sequence: | MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEG
RHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLA
LILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDS
DCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWF
RETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLAL
RLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSD
YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVED
YRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARL
TALRIKKTLQKISNSPEKPKVIQ
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| BDBM118134 |
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| n/a |
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| Name | BDBM118134 |
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| Synonyms: | US10017516, Compound 3 | US9682983, 3 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H21N7 |
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| Mol. Mass. | 407.4704 |
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| SMILES | C1CN(CCN1)c1ccc(nc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 |
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| Structure | 
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