| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Activin receptor type-1B |
|---|
| Ligand | BDBM143566 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ALK1-6 enzymatic assays |
|---|
| pH | 7.5±n/a |
|---|
| IC50 | 125±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Alimardanov, A; Cuny, GD; Grewal, GS; Lee, A; McKew, JC; Mohedas, AH; Shen, M; Xu, X; Yu, PB BMP inhibitors and methods of use thereof US Patent US9682983 Publication Date 6/20/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Activin receptor type-1B |
|---|
| Name: | Activin receptor type-1B |
|---|
| Synonyms: | ACV1B_HUMAN | ACVR1B | ACVRLK4 | ALK4 | Activin receptor type-1B/Activin receptor-like kinase 4 (ALK-4) |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 56810.99 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_587064 |
|---|
| Residue: | 505 |
|---|
| Sequence: | MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD
GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS
MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ
DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE
ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT
IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH
DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG
GVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYAN
GAARLTALRIKKTLSQLSVQEDVKI
|
|
|
|---|
| BDBM143566 |
|---|
| n/a |
|---|
| Name | BDBM143566 |
|---|
| Synonyms: | US10017516, Compound 13 | US9682983, 13 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H25N5 |
|---|
| Mol. Mass. | 419.5209 |
|---|
| SMILES | Cc1cc(-c2cnn3cc(cnc23)-c2ccc(cc2)C2CCNCC2)c2ccccc2n1 |
|---|
| Structure | 
|
|---|
Search and Browse
