| Reaction Details |
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 | Report a problem with these data |
| Target | Activin receptor type-1B |
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| Ligand | BDBM148356 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ALK1-6 enzymatic assays |
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| pH | 7.5±n/a |
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| IC50 | 2600±n/a nM |
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| Comments | extracted |
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| Citation |  Alimardanov, A; Cuny, GD; Grewal, GS; Lee, A; McKew, JC; Mohedas, AH; Shen, M; Xu, X; Yu, PB BMP inhibitors and methods of use thereof US Patent US9682983 Publication Date 6/20/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Activin receptor type-1B |
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| Name: | Activin receptor type-1B |
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| Synonyms: | ACV1B_HUMAN | ACVR1B | ACVRLK4 | ALK4 | Activin receptor type-1B/Activin receptor-like kinase 4 (ALK-4) |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56810.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_587064 |
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| Residue: | 505 |
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| Sequence: | MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD
GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS
MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ
DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE
ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT
IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH
DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG
GVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYAN
GAARLTALRIKKTLSQLSVQEDVKI
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| BDBM148356 |
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| n/a |
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| Name | BDBM148356 |
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| Synonyms: | US10017516, Compound 27 | US9682983, 27 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H23N7 |
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| Mol. Mass. | 421.497 |
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| SMILES | Nc1ccc2c(ccnc2c1)-c1cnn2cc(cnc12)-c1ccc(cc1)N1CCNCC1 |
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| Structure | 
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