| Reaction Details |
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 | Report a problem with these data |
| Target | Leucine-rich repeat serine/threonine-protein kinase 2 [970-2527,I2020T] |
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| Ligand | BDBM228657 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | LRRK2 Kinase Assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 1.4e+3± 2e+2 nM |
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| Comments | extracted |
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| Citation |  Ray, S; Bender, S; Kang, S; Lin, R; Glicksman, MA; Liu, M The Parkinson disease-linked LRRK2 protein mutation I2020T stabilizes an active state conformation leading to increased kinase activity. J Biol Chem289:13042-53 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Leucine-rich repeat serine/threonine-protein kinase 2 [970-2527,I2020T] |
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| Name: | Leucine-rich repeat serine/threonine-protein kinase 2 [970-2527,I2020T] |
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| Synonyms: | LRRK2 | LRRK2 t-I2020T | LRRK2_HUMAN | Leucine-rich repeat kinase 2 (LRRK2 t-I2020T) | PARK8 |
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| Type: | n/a |
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| Mol. Mass.: | 177305.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q5S007[970-2527,I2020T] |
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| Residue: | 1558 |
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| Sequence: | HSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSFPQQ
LCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFN
LSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFL
EACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQ
YLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLEN
LTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKA
VPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLV
LNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVIL
VGTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESL
NFKIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVRENQLQLDENEL
PHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPKHPKGIISRR
DVEKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSE
IIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSPEAYCL
VGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLK
KWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIM
LNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHH
PSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAM
IIYRDLKPHNVLLFTLYPNAAIIAKIADYGTAQYCCRMGIKTSEGTPGFRAPEVARGNVI
YNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEK
LIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWL
GCGHTDRGQLSFLDLNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINT
EDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLK
ILNIGNVSTPLMCLSESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAF
SDSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREVMVKENKESKHKMS
YSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMTAQLGSLKNV
MLVLGYNRKNTEGTQKQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTSVE
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| BDBM228657 |
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| n/a |
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| Name | BDBM228657 |
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| Synonyms: | GSK3-XIII |
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| Type | Small organic molecule |
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| Emp. Form. | C18H15N5 |
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| Mol. Mass. | 301.3452 |
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| SMILES | Cc1cc(Nc2nc(nc3ccccc23)-c2ccccc2)n[nH]1 |
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| Structure | 
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