| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-galactosidase [24-677,I51T] |
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| Ligand | BDBM228800 |
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| Substrate/Competitor | 4-Methylumbelliferyl-β-D-galactopyranoside |
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| Meas. Tech. | β-Gal Inhibitory Assay |
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| pH | 4.5±n/a |
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| Temperature | 310.15±n/a K |
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| Ki | 1.2e+3±n/a nM |
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| Citation |  Suzuki, H; Ohto, U; Higaki, K; Mena-Barragán, T; Aguilar-Moncayo, M; Ortiz Mellet, C; Nanba, E; Garcia Fernandez, JM; Suzuki, Y; Shimizu, T Structural basis of pharmacological chaperoning for human ß-galactosidase. J Biol Chem289:14560-8 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-galactosidase [24-677,I51T] |
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| Name: | Beta-galactosidase [24-677,I51T] |
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| Synonyms: | BGAL_HUMAN | ELNR1 | GLB1 | beta-Galactosidase (β-Gal)(I51T) |
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| Type: | Enzyme |
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| Mol. Mass.: | 73576.18 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human β-Gal (24-677 aa) with I51T mutation |
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| Residue: | 654 |
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| Sequence: | LRNATQRMFEIDYSRDSFLKDGQPFRYTSGSIHYSRVPRFYWKDRLLKMKMAGLNAIQTY
VPWNFHEPWPGQYQFSEDHDVEYFLRLAHELGLLVILRPGPYICAEWEMGGLPAWLLEKE
SILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPVITVQVENEYGSYFACDFDYLRFL
QKRFRHHLGDDVVLFTTDGAHKTFLKCGALQGLYTTVDFGTGSNITDAFLSQRKCEPKGP
LINSEFYTGWLDHWGQPHSTIKTEAVASSLYDILARGASVNLYMFIGGTNFAYWNGANSP
YAAQPTSYDYDAPLSEAGDLTEKYFALRNIIQKFEKVPEGPIPPSTPKFAYGKVTLEKLK
TVGAALDILCPSGPIKSLYPLTFIQVKQHYGFVLYRTTLPQDCSNPAPLSSPLNGVHDRA
YVAVDGIPQGVLERNNVITLNITGKAGATLDLLVENMGRVNYGAYINDFKGLVSNLTLSS
NILTDWTIFPLDTEDAVRSHLGGWGHRDSGHHDEAWAHNSSNYTLPAFYMGNFSIPSGIP
DLPQDTFIQFPGWTKGQVWINGFNLGRYWPARGPQLTLFVPQHILMTSAPNTITVLELEW
APCSSDDPELCAVTFVDRPVIGSSVTYDHPSKPVEKRLMPPPPQKNKDSWLDHV
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| BDBM228800 |
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| 4-Methylumbelliferyl-β-D-galactopyranoside |
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| Name | BDBM228800 |
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| Synonyms: | NOEV | Sapienic acid (SpA) |
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| Type | Small organic molecule |
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| Emp. Form. | C15H29NO4 |
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| Mol. Mass. | 287.3951 |
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| SMILES | CCCCCCCCN[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O |t:10| |
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| Structure | 
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