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TargetProteinase-activated receptor 1
LigandBDBM230664
Substrate/Competitorn/a
Meas. Tech.High Throughput Thrombin Receptor Radioligand Binding Assay
pH7.5±n/a
Ki 3±n/a nM
Commentsextracted
Citation Mandal MBlizzard TAChen HChobanian HGuo YPio BWu ZBiftu TGreenlee WJZhu JZ Preparation and use of bicyclic himbacine derivatives as PAR-1 receptor antagonists US Patent  US9340530 Publication Date 5/17/2016
More Info.:Get all data from this article,  Assay Method
 
Proteinase-activated receptor 1
Name:Proteinase-activated receptor 1
Synonyms:Coagulation factor II receptor | PAR-1 | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1)
Type:Protein
Mol. Mass.:47450.07
Organism:Homo sapiens (Human)
Description:P25116
Residue:425
Sequence:
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEE
KNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLN
IMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTA
AFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLK
EQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSS
AVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVS
SISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIY
KKLLT
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  Blast E-value cutoff:
BDBM230664
n/a
NameBDBM230664
Synonyms:US9340530, 2
TypeSmall organic molecule
Emp. Form.C23H22F3NO2
Mol. Mass.401.4215
SMILESC[C@H]1OC(=O)C2CC(F)(F)[C@@H](C)[C@H](\C=C\c3ccc(cn3)-c3cccc(F)c3)C12 |r|
Structure
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