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TargetTyrosine-protein kinase ABL1 [64-515]
LigandBDBM230775
Substrate/Competitorn/a
Meas. Tech.Radiometric Filter-Binding Assay
pH7.5±n/a
Temperature298.15±n/a K
IC50<0.1±n/a nM
Commentsextracted
Citation Furet, PGrotzfeld, RMJahnke, WJones, DBManley, PWMarzinzik, APelle, XFSalem, BSchoepfer, J Benzamide derivatives for inhibiting the activity of ABL1, ABL2 and BCR-ABL1 US Patent US9340537 Publication Date 5/17/2016
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase ABL1 [64-515]
Name:Tyrosine-protein kinase ABL1 [64-515]
Synonyms:ABL | ABL1 | ABL1_HUMAN | JTK7 | Tyrosine-protein kinase ABL1 | Tyrosine-protein kinase ABL1 (64-515) | Tyrosine-protein kinase ABL1 (ABL) | Tyrosine-protein kinase ABL1 (ABL1)
Type:Enzyme Catalytic Domain
Mol. Mass.:51539.77
Organism:Homo sapiens (Human)
Description:aa 64-515
Residue:452
Sequence:
NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLE
KHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGK
LYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDIT
MKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLG
VCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRD
LAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVW
AFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDR
PSFAEIHQAFETMFQESSISDEVEKELGKQGV
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  Blast E-value cutoff:
BDBM230775
n/a
NameBDBM230775
Synonyms:US9340537, 29 | US9896444, Example 29
TypeSmall organic molecule
Emp. Form.C23H19F3N4O4
Mol. Mass.472.4166
SMILESO[C@H]1CN(C[C@@H]1O)c1ccc(cc1-c1ccc([nH]1)C#N)C(=O)Nc1ccc(OC(F)(F)F)cc1 |r|
Structure
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