Reaction Details |
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Target | Tyrosine-protein kinase ABL1 [64-515] |
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Ligand | BDBM230775 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Radiometric Filter-Binding Assay |
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pH | 7.5±n/a |
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Temperature | 298.15±n/a K |
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IC50 | <0.1±n/a nM |
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Comments | extracted |
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Citation | Furet, P; Grotzfeld, RM; Jahnke, W; Jones, DB; Manley, PW; Marzinzik, A; Pelle, XF; Salem, B; Schoepfer, J Benzamide derivatives for inhibiting the activity of ABL1, ABL2 and BCR-ABL1 US Patent US9340537 Publication Date 5/17/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase ABL1 [64-515] |
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Name: | Tyrosine-protein kinase ABL1 [64-515] |
Synonyms: | ABL | ABL1 | ABL1_HUMAN | JTK7 | Tyrosine-protein kinase ABL1 | Tyrosine-protein kinase ABL1 (64-515) | Tyrosine-protein kinase ABL1 (ABL) | Tyrosine-protein kinase ABL1 (ABL1) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 51539.77 |
Organism: | Homo sapiens (Human) |
Description: | aa 64-515 |
Residue: | 452 |
Sequence: | NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLE
KHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGK
LYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDIT
MKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLG
VCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRD
LAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVW
AFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDR
PSFAEIHQAFETMFQESSISDEVEKELGKQGV
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BDBM230775 |
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n/a |
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Name | BDBM230775 |
Synonyms: | US9340537, 29 | US9896444, Example 29 |
Type | Small organic molecule |
Emp. Form. | C23H19F3N4O4 |
Mol. Mass. | 472.4166 |
SMILES | O[C@H]1CN(C[C@@H]1O)c1ccc(cc1-c1ccc([nH]1)C#N)C(=O)Nc1ccc(OC(F)(F)F)cc1 |r| |
Structure |
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