Reaction Details |
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Target | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI |
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Ligand | BDBM190653 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition Kinetics Assay |
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pH | 7.5±n/a |
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Ki | 11.0±0.4 nM |
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Comments | extracted |
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Citation | Schiebel, J; Chang, A; Shah, S; Lu, Y; Liu, L; Pan, P; Hirschbeck, MW; Tareilus, M; Eltschkner, S; Yu, W; Cummings, JE; Knudson, SE; Bommineni, GR; Walker, SG; Slayden, RA; Sotriffer, CA; Tonge, PJ; Kisker, C Rational design of broad spectrum antibacterial activity based on a clinically relevant enoyl-acyl carrier protein (ACP) reductase inhibitor. J Biol Chem289:15987-6005 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI |
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Name: | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI |
Synonyms: | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI | Enoyl-acyl carrier protein reductase (FaBI) | FABI_STAA8 | NADPH-dependent enoyl-ACP reductase (FabI) | fabI |
Type: | Enzyme |
Mol. Mass.: | 28019.03 |
Organism: | Staphylococcus aureus |
Description: | Q2FZQ3 |
Residue: | 256 |
Sequence: | MLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEA
HLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDI
SSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGP
DNIRVNAISASPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSG
VTGENIHVDSGFHAIK
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BDBM190653 |
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n/a |
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Name | BDBM190653 |
Synonyms: | PT172 |
Type | Small organic molecule |
Emp. Form. | C18H22ClNO |
Mol. Mass. | 303.826 |
SMILES | CCCCCCc1ccn(Cc2ccccc2Cl)c(=O)c1 |
Structure |
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