Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI
LigandBDBM190653
Substrate/Competitorn/a
Meas. Tech.Inhibition Kinetics Assay
pH7.5±n/a
Ki 11.0±0.4 nM
Commentsextracted
Citation Schiebel, JChang, AShah, SLu, YLiu, LPan, PHirschbeck, MWTareilus, MEltschkner, SYu, WCummings, JEKnudson, SEBommineni, GRWalker, SGSlayden, RASotriffer, CATonge, PJKisker, C Rational design of broad spectrum antibacterial activity based on a clinically relevant enoyl-acyl carrier protein (ACP) reductase inhibitor. J Biol Chem289:15987-6005 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Name:Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Synonyms:Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI | Enoyl-acyl carrier protein reductase (FaBI) | FABI_STAA8 | NADPH-dependent enoyl-ACP reductase (FabI) | fabI
Type:Enzyme
Mol. Mass.:28019.03
Organism:Staphylococcus aureus
Description:Q2FZQ3
Residue:256
Sequence:
MLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEA
HLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDI
SSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGP
DNIRVNAISASPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSG
VTGENIHVDSGFHAIK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM190653
n/a
NameBDBM190653
Synonyms:PT172
TypeSmall organic molecule
Emp. Form.C18H22ClNO
Mol. Mass.303.826
SMILESCCCCCCc1ccn(Cc2ccccc2Cl)c(=O)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: