| Reaction Details |
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 | Report a problem with these data |
| Target | Histone demethylase UTY [818-1347,P1214I] |
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| Ligand | BDBM231631 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | AlphaScreen Assay |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| Kd | 3.5e+3± 1.1e+3 nM |
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| Comments | extracted |
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| Citation |  Walport, LJ; Hopkinson, RJ; Vollmar, M; Madden, SK; Gileadi, C; Oppermann, U; Schofield, CJ; Johansson, C Human UTY(KDM6C) is a male-specific N¿-methyl lysyl demethylase. J Biol Chem289:18302-13 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone demethylase UTY [818-1347,P1214I] |
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| Name: | Histone demethylase UTY [818-1347,P1214I] |
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| Synonyms: | KDM6C | Lysine-specific demethylase 6C (UTY(KDM6C))(P1214I) | UTY | UTY_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 60283.28 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human UTY(KDM6C) truncation (818-1347 aa) with P1214I mutation |
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| Residue: | 530 |
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| Sequence: | PLASHRSTSQILPSMSVSICPSSTEVLKACRNPGKNGLSNSCILLDKCPPPRPPTSPYPP
LPKDKLNPPTPSIYLENKRDAFFPPLHQFCTNPKNPVTVIRGLAGALKLDLGLFSTKTLV
EANNEHMVEVRTQLLQPADENWDPTGTKKIWRCESNRSHTTIAKYAQYQASSFQESLREE
NEKRTQHKDHSDNESTSSENSGRRRKGPFKTIKFGTNIDLSDNKKWKLQLHELTKLPAFA
RVVSAGNLLTHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVP
EDYWGVLNDFCEKNNLNFLMSSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQA
VGWCNNIAWNVGPLTACQYKLAVERYEWNKLKSVKSIVPMVHLSWNMARNIKVSDPKLFE
MIKYCLLKILKQYQTLREALVAAGKEVIWHGRTNDEPAHYCSICEVEVFNLLFVTNESNT
QKTYIVHCHDCARKTSKSLENFVVLEQYKMEDLIQVYDQFTLALSLSSSS
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| BDBM231631 |
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| n/a |
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| Name | BDBM231631 |
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| Synonyms: | Biotin-KAPRKQLATKAARKMe3SAPATGG | H3K27Me3 peptide |
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| Type | Small organic molecule |
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| Emp. Form. | C103H183N34O28S |
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| Mol. Mass. | 2377.831 |
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| SMILES | CC(C)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)NCC(O)=O |r| |
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| Structure | 
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