| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium/potassium-transporting ATPase subunit alpha-1/beta-1 |
|---|
| Ligand | BDBM231660 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Na,K-ATPase Inhibition Assay |
|---|
| Ki | 101±4.4 nM |
|---|
| Citation |  Katz, A; Tal, DM; Heller, D; Haviv, H; Rabah, B; Barkana, Y; Marcovich, AL; Karlish, SJ Digoxin derivatives with enhanced selectivity for the a2 isoform of Na,K-ATPase: effects on intraocular pressure in rabbits. J Biol Chem289:21153-62 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium/potassium-transporting ATPase subunit alpha-1/beta-1 |
|---|
| Name: | Sodium/potassium-transporting ATPase subunit alpha-1/beta-1 |
|---|
| Synonyms: | Na,K-ATPase α1β1 | Na,K-ATPase alpha1beta1 | alpha1beta1FXYD1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | n/a |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Sodium/potassium-transporting ATPase subunit alpha-1 |
|---|
| Synonyms: | AT1A1_HUMAN | ATP1A1 | Na(+)/K(+) ATPase alpha-1 subunit | Na,K-ATPase isoform alpha-1 (α1) | Sodium pump subunit alpha-1 | Sodium/potassium-transporting ATPase subunit alpha-1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 112879.20 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P05023 |
|---|
| Residue: | 1023 |
|---|
| Sequence: | MGKGVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLS
RGLTSARAAEILARDGPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAA
TEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSI
NAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETR
NIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAV
FLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKN
LEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLA
LSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEI
PFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDAFQN
AYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVP
DAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDA
KACVVHGSDLKDMTSEQLDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVN
DSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTL
TSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPK
TDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPIHLLGLRVDWDDRWINDVED
SYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFE
ETALAAFLSYCPGMGVALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKE
TYY
|
|
|
|---|
| Component 2 |
| Name: | Sodium/potassium-transporting ATPase subunit beta-1 |
|---|
| Synonyms: | AT1B1_HUMAN | ATP1B | ATP1B1 | Na,K-ATPase isoform beta-1 (β1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 35067.44 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P05026 |
|---|
| Residue: | 303 |
|---|
| Sequence: | MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLT
ISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDD
MIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKL
NRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNVEYFGLGNSPGFPL
QYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSEKDRFQGRFDVKIE
VKS
|
|
|
|---|
| BDBM231660 |
|---|
| n/a |
|---|
| Name | BDBM231660 |
|---|
| Synonyms: | DMe (11) | US10668094, Compound DMe |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C42H67NO12 |
|---|
| Mol. Mass. | 777.9809 |
|---|
| SMILES | C[C@@H]1O[C@H](C[C@H](O)[C@@H]1O[C@H]1C[C@H](O)[C@H](OC2CCN(C)CC(C)O2)[C@H](C)O1)O[C@H]1CC[C@@]2(C)C(CCC3C2C[C@H](O)[C@]2(C)[C@H](CC[C@]32O)C2=CC(=O)OC2)C1 |r,t:54| |
|---|
| Structure | 
|
|---|
Search and Browse
