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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sodium/potassium-transporting ATPase subunit alpha-2/beta-1 | ||
| Ligand | BDBM50286739 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Na,K-ATPase Inhibition Assay | ||
| Ki | 90±14 nM | ||
| Citation |  Katz, A; Tal, DM; Heller, D; Haviv, H; Rabah, B; Barkana, Y; Marcovich, AL; Karlish, SJ Digoxin derivatives with enhanced selectivity for the a2 isoform of Na,K-ATPase: effects on intraocular pressure in rabbits. J Biol Chem289:21153-62 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sodium/potassium-transporting ATPase subunit alpha-2/beta-1 | |||
| Name: | Sodium/potassium-transporting ATPase subunit alpha-2/beta-1 | ||
| Synonyms: | Na,K-ATPase α2β1 | Na,K-ATPase alpha2beta1 | alpha2beta1FXYD1 | ||
| Type: | Protein | ||
| Mol. Mass.: | n/a | ||
| Description: | n/a | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | Sodium/potassium-transporting ATPase subunit alpha-2 | ||
| Synonyms: | AT1A2_HUMAN | ATP1A2 | KIAA0778 | Na,K-ATPase isoform alpha-2 (α2) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 112253.12 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P50993 | ||
| Residue: | 1020 | ||
| Sequence: |
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| Component 2 | |||
| Name: | Sodium/potassium-transporting ATPase subunit beta-1 | ||
| Synonyms: | AT1B1_HUMAN | ATP1B | ATP1B1 | Na,K-ATPase isoform beta-1 (β1) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 35067.44 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P05026 | ||
| Residue: | 303 | ||
| Sequence: |
| ||
| BDBM50286739 | |||
| n/a | |||
| Name | BDBM50286739 | ||
| Synonyms: | 4-((1R,3S,5S,8R,10R,11R,13R,14S,17R)-1,5,11,14-tetrahydroxy-10-(hydroxymethyl)-13-methyl-3-((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydro-2H-pyran-2-yloxy)-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)furan-2(5H)-one | 4-((1R,3S,5S,8R,9S,10R,11R,13R,14S,17R)-1,5,11,14-tetrahydroxy-10-(hydroxymethyl)-13-methyl-3-((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydro-2H-pyran-2-yloxy)-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)furan-2(5H)-one | 4-[(1R,3S,5S,10R,11R,13R,14S,17R)-1,5,11,14-Tetrahydroxy-10-hydroxymethyl-13-methyl-3-((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-5H-furan-2-one | 4-[(R)-1,5,11,14-Tetrahydroxy-10-hydroxymethyl-13-methyl-3-(3,4,5-trihydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-5H-furan-2-one | 4-[1,5,11,14-Tetrahydroxy-10-hydroxymethyl-13-methyl-3-(3,4,5-trihydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-5H-furan-2-one | 4-[1,5,11,14-Tetrahydroxy-10-hydroxymethyl-13-methyl-3-(3,4,5-trihydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-5H-furan-2-one(Ouabain) | CHEMBL222863 | NSC-25485 | Ouabain | Ouabain4-[1,5,11,14-Tetrahydroxy-10-hydroxymethyl-13-methyl-3-(3,4,5-trihydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-5H-furan-2-one | cid_439501 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H44O12 | ||
| Mol. Mass. | 584.6525 | ||
| SMILES | C[C@@H]1O[C@@H](O[C@H]2C[C@@H](O)[C@]3(CO)[C@H]4[C@H](O)C[C@]5(C)[C@H](CC[C@]5(O)[C@@H]4CC[C@]3(O)C2)C2=CC(=O)OC2)[C@H](O)[C@H](O)[C@H]1O |r,t:33| | ||
| Structure | 
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