| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium/potassium-transporting ATPase subunit alpha-2/beta-1 |
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| Ligand | BDBM231661 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Na,K-ATPase Inhibition Assay |
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| Ki | 18.5±4.9 nM |
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| Citation |  Katz, A; Tal, DM; Heller, D; Haviv, H; Rabah, B; Barkana, Y; Marcovich, AL; Karlish, SJ Digoxin derivatives with enhanced selectivity for the a2 isoform of Na,K-ATPase: effects on intraocular pressure in rabbits. J Biol Chem289:21153-62 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium/potassium-transporting ATPase subunit alpha-2/beta-1 |
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| Name: | Sodium/potassium-transporting ATPase subunit alpha-2/beta-1 |
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| Synonyms: | Na,K-ATPase α2β1 | Na,K-ATPase alpha2beta1 | alpha2beta1FXYD1 |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Sodium/potassium-transporting ATPase subunit alpha-2 |
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| Synonyms: | AT1A2_HUMAN | ATP1A2 | KIAA0778 | Na,K-ATPase isoform alpha-2 (α2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 112253.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P50993 |
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| Residue: | 1020 |
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| Sequence: | MGRGAGREYSPAATTAENGGGKKKQKEKELDELKKEVAMDDHKLSLDELGRKYQVDLSKG
LTNQRAQDVLARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAAME
DEPSNDNLYLGVVLAAVVIVTGCFSYYQEAKSSKIMDSFKNMVPQQALVIREGEKMQINA
EEVVVGDLVEVKGGDRVPADLRIISSHGCKVDNSSLTGESEPQTRSPEFTHENPLETRNI
CFFSTNCVEGTARGIVIATGDRTVMGRIATLASGLEVGRTPIAMEIEHFIQLITGVAVFL
GVSFFVLSLILGYSWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLE
AVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGATFDKRSPTWTALS
RIAGLCNRAVFKAGQENISVSKRDTAGDASESALLKCIELSCGSVRKMRDRNPKVAEIPF
NSTNKYQLSIHEREDSPQSHVLVMKGAPERILDRCSTILVQGKEIPLDKEMQDAFQNAYM
ELGGLGERVLGFCQLNLPSGKFPRGFKFDTDELNFPTEKLCFVGLMSMIDPPRAAVPDAV
GKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPMSQVNPREAKAC
VVHGSDLKDMTSEQLDEILKNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSP
ALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSN
IPEITPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEAAESDIMKRQPRNSQTDK
LVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPSRLLGIRLDWDDRTMNDLEDSYG
QEWTYEQRKVVEFTCHTAFFASIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLLEETA
LAAFLSYCPGMGVALRMYPLKVTWWFCAFPYSLLIFIYDEVRKLILRRYPGGWVEKETYY
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| Component 2 |
| Name: | Sodium/potassium-transporting ATPase subunit beta-1 |
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| Synonyms: | AT1B1_HUMAN | ATP1B | ATP1B1 | Na,K-ATPase isoform beta-1 (β1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 35067.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P05026 |
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| Residue: | 303 |
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| Sequence: | MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLT
ISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDD
MIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKL
NRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNVEYFGLGNSPGFPL
QYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSEKDRFQGRFDVKIE
VKS
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| BDBM231661 |
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| n/a |
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| Name | BDBM231661 |
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| Synonyms: | DEt (12) | US10668094, Compound DEt |
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| Type | Small organic molecule |
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| Emp. Form. | C43H69NO12 |
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| Mol. Mass. | 792.0075 |
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| SMILES | CCN1CCC(O[C@H]2[C@@H](O)C[C@H](O[C@H]3[C@@H](O)C[C@H](O[C@H]4CC[C@@]5(C)C(CCC6C5C[C@H](O)[C@]5(C)[C@H](CC[C@]65O)C5=CC(=O)OC5)C4)O[C@H]3C)O[C@H]2C)OC(C)C1 |r,t:42| |
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| Structure | 
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