| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Voltage-dependent calcium channel gamma-2 subunit |
|---|
| Ligand | BDBM292054 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biological Assays Calcium Flux Assay |
|---|
| pH | 7.4±n/a |
|---|
| IC50 | 0.050±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Ameriks, MK; Laforteza, BN; Savall, BM; Wade, WS; Meyer, ST; Gyuris, M 3-aryl-2H-pyrazolo[4,3-b]pyridine compounds and their use as AMPA receptor modulators US Patent US10100045 Publication Date 10/16/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Voltage-dependent calcium channel gamma-2 subunit |
|---|
| Name: | Voltage-dependent calcium channel gamma-2 subunit |
|---|
| Synonyms: | CACNG2 | CCG2_HUMAN | Neuronal voltage-gated calcium channel gamma-2 subunit | TARP gamma-2 | Transmembrane AMPAR regulatory protein gamma-2 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 35977.54 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 323 |
|---|
| Sequence: | MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEVMTH
SGLWRTCCLEGNFKGLCKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVILLFMGGL
CIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISANAGDPSKSDSKKNSYSYGWSF
YFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQASAITRIPSYRYRYQRRSRSS
SRSTEPSHSRDASPVGIKGFNTLPSTEISMYTLSRDPLKAATTPTATYNSDRDNSFLQVH
NCIQKENKDSLHSNTANRRTTPV
|
|
|
|---|
| BDBM292054 |
|---|
| n/a |
|---|
| Name | BDBM292054 |
|---|
| Synonyms: | 5-(2-Cyclobutyl-5-(trifluoromethyl)-2H-pyrazolo[4,3-b]pyridin-3-yl)-7- | US10100045, Example 25 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H17F3N4O |
|---|
| Mol. Mass. | 386.3704 |
|---|
| SMILES | Cc1cc(cc2CC(=O)Nc12)-c1n(nc2ccc(nc12)C(F)(F)F)C1CCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
