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TargetcDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1
LigandBDBM233042
Substrate/Competitorn/a
Meas. Tech.5α-Reductase Activity Assay
pH6.5±0
Temperature310.15±0 K
IC50 22±0.0 nM
Citation Bratoeff, EZambrano, AHeuze, IPalacios, ARamírez, DCabeza, M Synthesis and biological activity of progesterone derivatives as 5alpha-reductase inhibitors, and their effect on hamster prostate weight. J Enzyme Inhib Med Chem25:306-11 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
cDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1
Name:cDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1
Synonyms:5-alpha-Reductase (5α-Reductase)
Type:Enzyme
Mol. Mass.:24182.16
Organism:Homo sapiens (Human)
Description:EC 1.3.99.5; B7Z4L2
Residue:212
Sequence:
MEHAAQPWRWQRRRGWRRSACWPRSPTCSAPWAARSSRGIVRRTQCTAATRCPATGSECR
RGPPGWCRSCPRWPCRSTSTPASPPRVSAARPTASSWPCSSSTTGIGFGLWLTGMLINIH
SDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFC
FLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM233042
n/a
NameBDBM233042
Synonyms:3,20-Dioxo-6,7-epoxypregn-4-ene-7α-yl acetate (8)
TypeSmall organic molecule
Emp. Form.C23H30O5
Mol. Mass.386.4813
SMILESCC(=O)O[C@@]1(CCC2C3[C@@H]4O[C@@H]4C4=CC(=O)CC[C@]4(C)C3CC[C@]12C)C(C)=O |r,t:13|
Structure
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