Reaction Details |
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Target | cDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
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Ligand | BDBM233042 |
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Substrate/Competitor | n/a |
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Meas. Tech. | 5α-Reductase Activity Assay |
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pH | 6.5±0 |
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Temperature | 310.15±0 K |
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IC50 | 22±0.0 nM |
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Citation | Bratoeff, E; Zambrano, A; Heuze, I; Palacios, A; Ramírez, D; Cabeza, M Synthesis and biological activity of progesterone derivatives as 5alpha-reductase inhibitors, and their effect on hamster prostate weight. J Enzyme Inhib Med Chem25:306-11 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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cDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
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Name: | cDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
Synonyms: | 5-alpha-Reductase (5α-Reductase) |
Type: | Enzyme |
Mol. Mass.: | 24182.16 |
Organism: | Homo sapiens (Human) |
Description: | EC 1.3.99.5; B7Z4L2 |
Residue: | 212 |
Sequence: | MEHAAQPWRWQRRRGWRRSACWPRSPTCSAPWAARSSRGIVRRTQCTAATRCPATGSECR
RGPPGWCRSCPRWPCRSTSTPASPPRVSAARPTASSWPCSSSTTGIGFGLWLTGMLINIH
SDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFC
FLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF
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BDBM233042 |
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n/a |
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Name | BDBM233042 |
Synonyms: | 3,20-Dioxo-6,7-epoxypregn-4-ene-7α-yl acetate (8) |
Type | Small organic molecule |
Emp. Form. | C23H30O5 |
Mol. Mass. | 386.4813 |
SMILES | CC(=O)O[C@@]1(CCC2C3[C@@H]4O[C@@H]4C4=CC(=O)CC[C@]4(C)C3CC[C@]12C)C(C)=O |r,t:13| |
Structure |
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