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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase pim-1 | ||
| Ligand | BDBM162014 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | PIM-1 Biochemical Assay | ||
| IC50 | <100±n/a nM | ||
| Citation |  Pastor Fernández, J; Ramos Lima, FJ; Hernandez Higueras, AI; Martínez González, S; Martín Hernando, JI; Saluste, CP; Gonzalez Cantalapiedra, E; Blanco Aparicio, C; Rodríguez Hergueta, A; Garcia Collazo, AM; Salgado Serrano, A; Noya Marino, B Tricyclic compounds for use as kinase inhibitors US Patent US9682991 Publication Date 6/20/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase pim-1 | |||
| Name: | Serine/threonine-protein kinase pim-1 | ||
| Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) | ||
| Type: | Protein | ||
| Mol. Mass.: | 35681.82 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P11309 | ||
| Residue: | 313 | ||
| Sequence: |
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| BDBM162014 | |||
| n/a | |||
| Name | BDBM162014 | ||
| Synonyms: | US9682991, 70 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H24F3N7O2 | ||
| Mol. Mass. | 463.4562 | ||
| SMILES | CN1CCOc2c1c(N[C@@H]1CC[C@H](N)CC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1 |r,wU:9.9,12.13,(-6.57,2.69,;-5.24,3.47,;-5.24,5,;-3.91,5.78,;-2.57,5,;-2.57,3.47,;-3.91,2.69,;-3.91,1.15,;-5.24,.38,;-5.24,-1.15,;-6.57,-1.93,;-6.57,-3.47,;-5.24,-4.23,;-5.24,-5.78,;-3.91,-3.47,;-3.91,-1.93,;-2.57,.38,;-1.24,1.15,;.23,.68,;1.13,1.93,;.23,3.17,;-1.24,2.69,;.62,-.81,;-.46,-1.9,;-.07,-3.38,;1.42,-3.78,;2.51,-2.69,;4,-3.09,;5.09,-2,;6.57,-2.4,;4.69,-.52,;5.86,-3.34,;2.11,-1.21,)| | ||
| Structure | 
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