| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-1 |
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| Ligand | BDBM162017 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PIM-1 Biochemical Assay |
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| IC50 | <100±n/a nM |
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| Citation |  Pastor Fernández, J; Ramos Lima, FJ; Hernandez Higueras, AI; Martínez González, S; Martín Hernando, JI; Saluste, CP; Gonzalez Cantalapiedra, E; Blanco Aparicio, C; Rodríguez Hergueta, A; Garcia Collazo, AM; Salgado Serrano, A; Noya Marino, B Tricyclic compounds for use as kinase inhibitors US Patent US9682991 Publication Date 6/20/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-1 |
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| Name: | Serine/threonine-protein kinase pim-1 |
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| Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) |
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| Type: | Protein |
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| Mol. Mass.: | 35681.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11309 |
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| Residue: | 313 |
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| Sequence: | MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
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| BDBM162017 |
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| n/a |
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| Name | BDBM162017 |
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| Synonyms: | US9682991, 73 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H30F3N7O2 |
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| Mol. Mass. | 505.5359 |
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| SMILES | CN1CCC(CNc2nn3c(nnc3c3OCC(C)(C)N(C)c23)-c2cccc(OC(F)(F)F)c2)CC1 |
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| Structure | 
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