| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-3 |
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| Ligand | BDBM162043 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PIM-3 Biochemical Assay |
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| IC50 | <100±n/a nM |
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| Citation |  Pastor Fernández, J; Ramos Lima, FJ; Hernandez Higueras, AI; Martínez González, S; Martín Hernando, JI; Saluste, CP; Gonzalez Cantalapiedra, E; Blanco Aparicio, C; Rodríguez Hergueta, A; Garcia Collazo, AM; Salgado Serrano, A; Noya Marino, B Tricyclic compounds for use as kinase inhibitors US Patent US9682991 Publication Date 6/20/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-3 |
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| Name: | Serine/threonine-protein kinase pim-3 |
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| Synonyms: | PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3) |
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| Type: | Protein |
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| Mol. Mass.: | 35888.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q86V86 |
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| Residue: | 326 |
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| Sequence: | MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI
ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL
LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL
RSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVC
GDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGV
PESCDLRLCTLDPDDVASTTSSSESL
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| BDBM162043 |
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| n/a |
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| Name | BDBM162043 |
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| Synonyms: | US9682991, 97 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23F3N6O3 |
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| Mol. Mass. | 464.4409 |
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| SMILES | CN(C1CCOCC1)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1 |
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| Structure | 
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