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TargetUDP-glucuronosyltransferase 1A4
LigandBDBM50014323
Substrate/CompetitorMidazolam
Meas. Tech.UDP-glucuronosyltransferase Activity Assay
IC50 2.3e+4± 6e+3 nM
Citation Liu, YShe, MWu, ZDai, R The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors. J Enzyme Inhib Med Chem26:386-93 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
UDP-glucuronosyltransferase 1A4
Name:UDP-glucuronosyltransferase 1A4
Synonyms:Bilirubin-specific UDPGT isozyme 2 | GNT1 | GNT1 | UD14_HUMAN | UDP-glucuronosyltransferase 1-4 | UDP-glucuronosyltransferase 1-D | UDP-glucuronosyltransferase 1A4 | UDPGT 1-4 | UGT-1D | UGT1 | UGT1*4 | UGT1-04 | UGT1.4 | UGT1A4 | UGT1D | Uridine-5'-diphosphoglucuronosyltransferase 1A4 | hUG-BR2
Type:Enzyme
Mol. Mass.:60042.50
Organism:Homo sapiens (Human)
Description:P22310
Residue:534
Sequence:
MARGLQVPLPRLATGLLLLLSVQPWAESGKVLVVPTDGSPWLSMREALRELHARGHQAVV
LTPEVNMHIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFETEHLLKRYSRSMAIMNNV
SLALHRCCVELLHNEALIRHLNATSFDVVLTDPVNLCGAVLAKYLSIPAVFFWRYIPCDL
DFKGTQCPNPSSYIPKLLTTNSDHMTFLQRVKNMLYPLALSYICHTFSAPYASLASELFQ
REVSVVDLVSYASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND
LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT
SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH
DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50014323
Midazolam
NameBDBM50014323
Synonyms:2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE | 2-Phenyl-benzo[h]chromen-4-one | 7,8-Benzoflavone | CHEMBL283196 | alpha-naphthoflavone
TypeSmall organic molecule
Emp. Form.C19H12O2
Mol. Mass.272.2974
SMILESO=c1cc(oc2c3ccccc3ccc12)-c1ccccc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: