| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-glucuronosyltransferase 1A4 |
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| Ligand | BDBM50121975 |
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| Substrate/Competitor | Midazolam |
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| Meas. Tech. | UDP-glucuronosyltransferase Activity Assay |
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| IC50 | 1.66e+5± 1.8e+4 nM |
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| Citation |  Liu, Y; She, M; Wu, Z; Dai, R The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors. J Enzyme Inhib Med Chem26:386-93 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| UDP-glucuronosyltransferase 1A4 |
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| Name: | UDP-glucuronosyltransferase 1A4 |
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| Synonyms: | Bilirubin-specific UDPGT isozyme 2 | GNT1 | GNT1 | UD14_HUMAN | UDP-glucuronosyltransferase 1-4 | UDP-glucuronosyltransferase 1-D | UDP-glucuronosyltransferase 1A4 | UDPGT 1-4 | UGT-1D | UGT1 | UGT1*4 | UGT1-04 | UGT1.4 | UGT1A4 | UGT1D | Uridine-5'-diphosphoglucuronosyltransferase 1A4 | hUG-BR2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 60042.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22310 |
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| Residue: | 534 |
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| Sequence: | MARGLQVPLPRLATGLLLLLSVQPWAESGKVLVVPTDGSPWLSMREALRELHARGHQAVV
LTPEVNMHIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFETEHLLKRYSRSMAIMNNV
SLALHRCCVELLHNEALIRHLNATSFDVVLTDPVNLCGAVLAKYLSIPAVFFWRYIPCDL
DFKGTQCPNPSSYIPKLLTTNSDHMTFLQRVKNMLYPLALSYICHTFSAPYASLASELFQ
REVSVVDLVSYASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND
LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT
SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH
DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
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| BDBM50121975 |
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| Midazolam |
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| Name | BDBM50121975 |
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| Synonyms: | (6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol | CARDIOQUIN | CHEMBL1294 | CIN-QUIN | DURAQUIN | QUINACT | QUINAGLUTE | QUINALAN | QUINATIME | QUINIDEX | QUINIDINE | QUINORA | US9402878, Quinidine |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24N2O2 |
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| Mol. Mass. | 324.4168 |
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| SMILES | COc1ccc2nccc([C@H](O)[C@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1 |r,THB:20:19:12.13:16.15,10:12:18.19:16.15| |
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| Structure | 
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