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TargetUridine-5'-diphosphoglucuronosyltransferase 1A6
LigandBDBM50014323
Substrate/Competitor1-Naphthol
Meas. Tech.UDP-glucuronosyltransferase Activity Assay
IC50 6.7e+4± 8e+3 nM
Citation Liu YShe MWu ZDai R The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors. J Enzyme Inhib Med Chem 26:386-93 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Uridine-5'-diphosphoglucuronosyltransferase 1A6
Name:Uridine-5'-diphosphoglucuronosyltransferase 1A6
Synonyms:Phenol-metabolizing UDP-glucuronosyltransferase | UDP-glucuronosyltransferase 1-6 | UDP-glucuronosyltransferase 1-F | UDP-glucuronosyltransferase 1A6 | UDPGT 1-6 | UGT-1F | UGT1*6 | UGT1-06 | UGT1.6 | UGT1F
Type:Enzyme
Mol. Mass.:60765.14
Organism:Homo sapiens (Human)
Description:P19224
Residue:532
Sequence:
MACLLRSFQRISAGVFFLALWGMVVGDKLLVVPQDGSHWLSMKDIVEVLSDRGHEIVVVV
PEVNLLLKESKYYTRKIYPVPYDQEELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIG
LYFINCQSLLQDRDTLNFFKESKFDALFTDPALPCGVILAEYLGLPSVYLFRGFPCSLEH
TFSRSPDPVSYIPRCYTKFSDHMTFSQRVANFLVNLLEPYLFYCLFSKYEELASAVLKRD
VDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCKKRKDLSQEFEAYINASGEHG
IVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLL
GHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSE
DLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDL
TWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50014323
1-Naphthol
NameBDBM50014323
Synonyms:2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE | 2-Phenyl-benzo[h]chromen-4-one | 7,8-Benzoflavone | CHEMBL283196 | alpha-naphthoflavone
TypeSmall organic molecule
Emp. Form.C19H12O2
Mol. Mass.272.2974
SMILESO=c1cc(oc2c3ccccc3ccc12)-c1ccccc1
Structure
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