| Reaction Details |
|---|
 | Report a problem with these data |
| Target | UDP-glucuronosyltransferase 1-6 |
|---|
| Ligand | BDBM31768 |
|---|
| Substrate/Competitor | 1-Naphthol |
|---|
| Meas. Tech. | UDP-glucuronosyltransferase Activity Assay |
|---|
| IC50 | 1.9e+4± 2e+3 nM |
|---|
| Citation |  Liu, Y; She, M; Wu, Z; Dai, R The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors. J Enzyme Inhib Med Chem26:386-93 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| UDP-glucuronosyltransferase 1-6 |
|---|
| Name: | UDP-glucuronosyltransferase 1-6 |
|---|
| Synonyms: | GNT1 | Phenol-metabolizing UDP-glucuronosyltransferase | UD16_HUMAN | UDP-glucuronosyltransferase 1-6 | UDP-glucuronosyltransferase 1-F | UDP-glucuronosyltransferase 1A6 | UDPGT 1-6 | UGT-1F | UGT1 | UGT1*6 | UGT1-06 | UGT1.6 | UGT1A6 | UGT1F | Uridine-5'-diphosphoglucuronosyltransferase 1A6 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 60765.14 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P19224 |
|---|
| Residue: | 532 |
|---|
| Sequence: | MACLLRSFQRISAGVFFLALWGMVVGDKLLVVPQDGSHWLSMKDIVEVLSDRGHEIVVVV
PEVNLLLKESKYYTRKIYPVPYDQEELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIG
LYFINCQSLLQDRDTLNFFKESKFDALFTDPALPCGVILAEYLGLPSVYLFRGFPCSLEH
TFSRSPDPVSYIPRCYTKFSDHMTFSQRVANFLVNLLEPYLFYCLFSKYEELASAVLKRD
VDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCKKRKDLSQEFEAYINASGEHG
IVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLL
GHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSE
DLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDL
TWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
|
|
|
|---|
| BDBM31768 |
|---|
| 1-Naphthol |
|---|
| Name | BDBM31768 |
|---|
| Synonyms: | CHEMBL295698 | Ketoconazole | Nizoral | Panfungol |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H28Cl2N4O4 |
|---|
| Mol. Mass. | 531.431 |
|---|
| SMILES | CC(=O)N1CCN(CC1)c1ccc(OC[C@@H]2CO[C@](Cn3ccnc3)(O2)c2ccc(Cl)cc2Cl)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
