| Reaction Details |
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 | Report a problem with these data |
| Target | Cholesteryl ester transfer protein |
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| Ligand | BDBM234607 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Radioactive Assays of CETP-Catalyzed CE and TG Transfer (RTA Assay) |
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| pH | 7.4±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | 3±n/a nM |
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| Comments | extracted |
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| Citation |  Acton, III, JJ; Ye, F; Vachal, P; Sha, D; Dropinski, JF; Chu, L; Ondeyka, D; Kim, AJ; Colandrea, VJ; Zang, Y; Zhang, F; Dong, G Cyclic amine substituted heterocyclic CETP inhibitors US Patent US9353101 Publication Date 5/31/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholesteryl ester transfer protein |
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| Name: | Cholesteryl ester transfer protein |
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| Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
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| Type: | Enzyme |
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| Mol. Mass.: | 54751.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11597 |
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| Residue: | 493 |
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| Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
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| BDBM234607 |
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| n/a |
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| Name | BDBM234607 |
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| Synonyms: | US9353101, 3 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H27F7N6O3S |
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| Mol. Mass. | 696.638 |
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| SMILES | COc1ncc(cc1-c1cnc(nc1CN1[C@@H](C)[C@H](OC1=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)N1CC(F)C1)-c1sc(C)nc1C |r| |
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| Structure | 
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