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TargetCalcium/calmodulin-dependent protein kinase type II subunit delta
LigandBDBM292529
Substrate/Competitorn/a
Meas. Tech.CaMKII delta Biochemical Assay
IC50 0.110±n/a nM
Citation Elzein EKalla RVKoltun DLi XParkhill EQPerry TSimonovich SPZablocki JZiebenhaus CA Fused heterocyclic compounds as CaM kinase inhibitors US Patent  US10100058 Publication Date 10/16/2018  Article
More Info.:Get all data from this article,  Assay Method
 
Calcium/calmodulin-dependent protein kinase type II subunit delta
Name:Calcium/calmodulin-dependent protein kinase type II subunit delta
Synonyms:CAMK2D | CAMKD | CaM kinase II | CaM kinase II delta | CaMK-II subunit delta | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaMKII subunit delta)
Type:Enzyme
Mol. Mass.:56375.82
Organism:Homo sapiens (Human)
Description:Q13557
Residue:499
Sequence:
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLER
EARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQI
LESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY
LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDT
VTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKL
KGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEA
INNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVH
LVGDDAACIAYIRLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPTVPIKPP
CIPNGKENFSGGTSLWQNI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM292529
n/a
NameBDBM292529
Synonyms:(S)-N-(2-(diethylamino)propyl)-2-(3-ethylureido)-6-(5-(thiophen-2-yl)pyrazolo[1,5-a]pyrimidin-3-yl)isonicotinamide | US10100058, Example 185
TypeSmall organic molecule
Emp. Form.C26H32N8O2S
Mol. Mass.520.65
SMILESCCNC(=O)Nc1cc(cc(n1)-c1cnn2ccc(nc12)-c1cccs1)C(=O)NC[C@H](C)N(CC)CC |r|
Structure
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