| Reaction Details |
|---|
 | Report a problem with these data |
| Target | cDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
|---|
| Ligand | BDBM235659 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | 5α-Reductase Activity Assay |
|---|
| pH | 6.5±0 |
|---|
| Temperature | 310.15±0 K |
|---|
| IC50 | 50±6 nM |
|---|
| Citation |  Cabeza, M; Trejo, KV; González, C; García, P; Soriano, J; Heuze, Y; Bratoeff, E Steroidal 5a-reductase inhibitors using 4-androstenedione as substrate. J Enzyme Inhib Med Chem26:712-9 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| cDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
|---|
| Name: | cDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
|---|
| Synonyms: | 5-alpha-Reductase (5α-Reductase) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 24182.16 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | EC 1.3.99.5; B7Z4L2 |
|---|
| Residue: | 212 |
|---|
| Sequence: | MEHAAQPWRWQRRRGWRRSACWPRSPTCSAPWAARSSRGIVRRTQCTAATRCPATGSECR
RGPPGWCRSCPRWPCRSTSTPASPPRVSAARPTASSWPCSSSTTGIGFGLWLTGMLINIH
SDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFC
FLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF
|
|
|
|---|
| BDBM235659 |
|---|
| n/a |
|---|
| Name | BDBM235659 |
|---|
| Synonyms: | 4-Bromo-3,20-dioxopregn-4-ene-17-yl-4-ethylbenzoate (8b) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H37BrO4 |
|---|
| Mol. Mass. | 541.516 |
|---|
| SMILES | CCc1ccc(cc1)C(=O)O[C@@]1(CCC2C3CCC4=C(Br)C(=O)CCC4(C)C3CCC12C)C(C)=O |r,c:19| |
|---|
| Structure | 
|
|---|
Search and Browse
