Reaction Details | |||
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Target | 5-hydroxytryptamine receptor 2A/MAP kinase-activated protein kinase 2 | ||
Ligand | BDBM235961 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Inhibition Assay | ||
pH | 7.5±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 6.4±n/a nM | ||
Comments | extracted | ||
Citation | Selness, SR; Monahan, JB; Schindler, JF; Devadas, B Substituted pyridinone-pyridinyl compounds US Patent US9365546 Publication Date 6/14/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
5-hydroxytryptamine receptor 2A/MAP kinase-activated protein kinase 2 | |||
Name: | 5-hydroxytryptamine receptor 2A/MAP kinase-activated protein kinase 2 | ||
Synonyms: | p38 MAPK/ MAPKAP kinases MK2 | p38 MAPK/ MAPKAP kinases PRAK | ||
Type: | Protein | ||
Mol. Mass.: | n/a | ||
Description: | n/a | ||
Components: | This complex has 2 components. | ||
Component 1 | |||
Name: | 5-hydroxytryptamine receptor 2A | ||
Synonyms: | 5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A | ||
Type: | undefined | ||
Mol. Mass.: | 52607.65 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P28223 | ||
Residue: | 471 | ||
Sequence: |
| ||
Component 2 | |||
Name: | MAP kinase-activated protein kinase 2 | ||
Synonyms: | MAP kinase-activated protein kinase 2 (MAPKAPK2) | MAP kinase-activated protein kinase 2 (MK2) | MAP kinase-activated protein kinase 2 (p38/MK2) | MAPK-Activated Protein Kinase 2 (MK2) | MAPK-activated protein kinase 2 | MAPK2_HUMAN | MAPKAP kinase 2 | MAPKAPK-2 | MAPKAPK2 | MK2 | ||
Type: | Serine/threonine-protein kinase | ||
Mol. Mass.: | 45579.87 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P49137 | ||
Residue: | 400 | ||
Sequence: |
| ||
BDBM235961 | |||
n/a | |||
Name | BDBM235961 | ||
Synonyms: | US9365546, 284 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H23ClF2N4O3 | ||
Mol. Mass. | 512.936 | ||
SMILES | Cc1cnc(cc1-n1c(C)cc(OCc2ccc(F)cc2F)c(Cl)c1=O)-c1ccnc(n1)C(C)(C)O |(-5.33,-1.54,;-4,-2.31,;-4,-3.85,;-2.67,-4.62,;-1.33,-3.85,;-1.33,-2.31,;-2.67,-1.54,;-2.67,,;-1.33,.77,;;-1.33,2.31,;-2.67,3.08,;-2.67,4.62,;-1.33,5.39,;,4.62,;,3.08,;1.33,2.31,;2.67,3.08,;4,2.31,;2.67,4.62,;1.33,5.39,;1.33,6.93,;-4,2.31,;-5.33,3.08,;-4,.77,;-5.33,,;,-4.62,;,-6.16,;1.33,-6.93,;2.67,-6.16,;2.67,-4.62,;1.33,-3.85,;4,-3.85,;3.23,-2.52,;4.77,-2.52,;5.33,-4.62,)| | ||
Structure |