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TargetCellular tumor antigen p53 [18-26]/Protein Mdm4 [2-185]
LigandBDBM236254
Substrate/Competitorn/a
Meas. Tech.Time Resolved Fluorescence Energy Transfer (TR-FRET) Assay
Temperature298.15±n/a K
IC50 507.5±n/a nM
Commentsextracted
Citation Cotesta, SFuret, PGuagnano, VHolzer, PKallen, JMah, RMasuya, KSchlapbach, AStutz, SVaupel, A Pyrrolopyrrolidinone compounds US Patent US9365576 Publication Date 6/14/2016
More Info.:Get all data from this article,  Assay Method
 
Cellular tumor antigen p53 [18-26]/Protein Mdm4 [2-185]
Name:Cellular tumor antigen p53 [18-26]/Protein Mdm4 [2-185]
Synonyms:p53-MDM4
Type:Protein
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Cellular tumor antigen p53 [18-26]
Synonyms:P53 | P53_HUMAN | TP53 | Tumor suppressor p53
Type:Protein
Mol. Mass.:1122.31
Organism:Homo sapiens (Human)
Description:aa 18-26
Residue:9
Sequence:
TFSDLWKLL
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Component 2
Name:Protein Mdm4 [2-185]
Synonyms:E3 ubiquitin-protein ligase Mdm4 | MDM4 | MDM4_HUMAN | MDMX | p53-binding protein Mdm4
Type:Protein
Mol. Mass.:20438.64
Organism:Homo sapiens (Human)
Description:aa 2-185
Residue:184
Sequence:
TSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIM
VKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLA
LAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQD
ETSR
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BDBM236254
n/a
NameBDBM236254
Synonyms:US9365576, 7
TypeSmall organic molecule
Emp. Form.C31H28Cl2FN3O3
Mol. Mass.580.477
SMILESCNC(=O)c1ccc(OC)c(c1)-c1cc2C(=O)N([C@H](c2n1C(C)C)c1ccc(Cl)cc1C)c1cccc(Cl)c1F |r|
Structure
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