Ki Summary

Reaction Details

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Target

Cellular tumor antigen p53 [18-26]/Protein Mdm4 [2-185]

Ligand

BDBM236315

Substrate/Competitor

n/a

Meas. Tech.

Time Resolved Fluorescence Energy Transfer (TR-FRET) Assay

Temperature

298.15±n/a K

IC50

7858.6±n/a nM

Comments

extracted

Citation

Cotesta, S; Furet, P; Guagnano, V; Holzer, P; Kallen, J; Mah, R; Masuya, K; Schlapbach, A; Stutz, S; Vaupel, A Pyrrolopyrrolidinone compounds US Patent US9365576 Publication Date 6/14/2016

More Info.:

Get all data from this article, Assay Method

Cellular tumor antigen p53 [18-26]/Protein Mdm4 [2-185]

Name:

Cellular tumor antigen p53 [18-26]/Protein Mdm4 [2-185]

Synonyms:

p53-MDM4

Type:

Protein

Mol. Mass.:

n/a

Description:

n/a

Components:

This complex has 2 components.

Component 1

Name:

Cellular tumor antigen p53 [18-26]

Synonyms:

P53 | P53_HUMAN | TP53 | Tumor suppressor p53

Type:

Protein

Mol. Mass.:

1122.31

Organism:

Homo sapiens (Human)

Description:

aa 18-26

Residue:

Sequence:

TFSDLWKLL

Component 2

Name:

Protein Mdm4 [2-185]

Synonyms:

E3 ubiquitin-protein ligase Mdm4 | MDM4 | MDM4_HUMAN | MDMX | p53-binding protein Mdm4

Type:

Protein

Mol. Mass.:

20438.64

Organism:

Homo sapiens (Human)

Description:

aa 2-185

Residue:

184

Sequence:

TSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIM
VKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLA
LAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQD
ETSR

BDBM236315

n/a

Name

BDBM236315

Synonyms:

US9365576, 68

Type

Small organic molecule

Emp. Form.

C26H30ClN5O3

Mol. Mass.

496.001

SMILES

COc1nc(N)ncc1-c1cc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)[C@H]1CC[C@H](O)CC1 |r,wU:31.35,wD:28.31,(4.68,5.6,;3.91,4.26,;4.68,2.93,;6.22,2.93,;6.99,1.6,;8.53,1.6,;6.22,.26,;4.68,.26,;3.91,1.6,;2.37,1.6,;1.46,2.84,;,2.37,;-1.46,2.84,;-2.23,4.18,;-2.37,1.6,;-1.46,.35,;,.83,;1.46,.35,;1.86,-1.14,;.77,-2.22,;3.35,-1.53,;-1.86,-1.14,;-3.35,-1.53,;-3.75,-3.02,;-2.66,-4.11,;-3.06,-5.6,;-1.17,-3.71,;-.77,-2.22,;-3.91,1.6,;-4.68,2.93,;-6.22,2.93,;-6.99,1.6,;-8.53,1.6,;-6.22,.26,;-4.68,.26,)|

Structure