Reaction Details |
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Target | Cellular tumor antigen p53 [18-26]/E3 ubiquitin-protein ligase Mdm2 [2-188] |
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Ligand | BDBM236270 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Time Resolved Fluorescence Energy Transfer (TR-FRET) Assay |
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Temperature | 298.15±n/a K |
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IC50 | 0.065±n/a nM |
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Comments | extracted |
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Citation | Cotesta, S; Furet, P; Guagnano, V; Holzer, P; Kallen, J; Mah, R; Masuya, K; Schlapbach, A; Stutz, S; Vaupel, A Pyrrolopyrrolidinone compounds US Patent US9365576 Publication Date 6/14/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Cellular tumor antigen p53 [18-26]/E3 ubiquitin-protein ligase Mdm2 [2-188] |
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Name: | Cellular tumor antigen p53 [18-26]/E3 ubiquitin-protein ligase Mdm2 [2-188] |
Synonyms: | p53-MDM2 |
Type: | Protein |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Cellular tumor antigen p53 [18-26] |
Synonyms: | P53 | P53_HUMAN | TP53 | Tumor suppressor p53 |
Type: | Protein |
Mol. Mass.: | 1122.31 |
Organism: | Homo sapiens (Human) |
Description: | aa 18-26 |
Residue: | 9 |
Sequence: | |
Component 2 |
Name: | E3 ubiquitin-protein ligase Mdm2 [2-188] |
Synonyms: | E3 ubiquitin-protein ligase Mdm2 | MDM2 | MDM2_HUMAN |
Type: | Protein |
Mol. Mass.: | 21187.98 |
Organism: | Homo sapiens (Human) |
Description: | aa 2-188 |
Residue: | 187 |
Sequence: | CNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYI
MTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTS
VSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQR
KRHKSDS
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BDBM236270 |
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n/a |
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Name | BDBM236270 |
Synonyms: | US9365576, 23 |
Type | Small organic molecule |
Emp. Form. | C28H26Cl2N4O3 |
Mol. Mass. | 537.437 |
SMILES | COc1ncc(-c2cc3C(=O)N([C@H](c3n2C(C)C)c2ccc(Cl)cc2)c2cc(Cl)ccc2C)c(OC)n1 |r| |
Structure |
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