| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 2 |
|---|
| Ligand | BDBM236557 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Mobility Shift Assay |
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| pH | 7.5±n/a |
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| Temperature | 301.15±n/a K |
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| IC50 | >10000±n/a nM |
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| Comments | extracted |
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| Citation |  Wu, F; Shu, C PI3K and/or mTOR inhibitor US Patent US9365572 Publication Date 6/14/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Cyclin-dependent kinase 2 |
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| Name: | Cyclin-dependent kinase 2 |
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| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
|---|
| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33938.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24941 |
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| Residue: | 298 |
|---|
| Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
|
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|
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| BDBM236557 |
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| n/a |
|---|
| Name | BDBM236557 |
|---|
| Synonyms: | US9365572, 5 |
|---|
| Type | Small organic molecule |
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| Emp. Form. | C22H13F3N6O2 |
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| Mol. Mass. | 450.3728 |
|---|
| SMILES | Nc1ccc(cn1)-c1ccc2ncc3c(n(-c4cccc(c4)C(F)(F)F)c(=O)[nH]c3=O)c2n1 |
|---|
| Structure | 
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