Ki Summary

Reaction Details

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Target

Apoptosis regulator Bcl-2

Ligand

BDBM237168

Substrate/Competitor

n/a

Meas. Tech.

Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) Assay

Temperature

298.15±n/a K

<0.010±n/a nM

Comments

extracted

Citation

Tao, Z; Wang, X; Souers, AJ; Catron, ND; Sullivan, GM Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases US Patent US9403822 Publication Date 8/2/2016

More Info.:

Get all data from this article, Assay Method

Apoptosis regulator Bcl-2

Name:

Apoptosis regulator Bcl-2

Synonyms:

Type:

Homodimer or heterodimer

Mol. Mass.:

26269.11

Organism:

Homo sapiens (Human)

Description:

P10415

Residue:

239

Sequence:

MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK

BDBM237168

n/a

Name

BDBM237168

Synonyms:

US9403822, 1

Type

Small organic molecule

Emp. Form.

C48H57ClN7O11PS

Mol. Mass.

1006.498

SMILES

CO[C@H]1CC[C@H](CNc2ccc(cc2[N+]([O-])=O)S(=O)(=O)NC(=O)c2ccc(cc2Oc2cn(COP(O)(O)=O)c3nccc3c2)N2CCN(CC3=C(CC(C)(C)CC3)c3ccc(Cl)cc3)CC2)CC1 |r,wU:2.1,wD:5.5,t:54,(2.67,20.02,;4,19.25,;4,17.71,;5.33,16.94,;5.33,15.4,;4,14.63,;4,13.09,;5.33,12.32,;5.33,10.78,;6.67,10.01,;6.67,8.47,;5.33,7.7,;4,8.47,;4,10.01,;2.67,10.78,;1.33,10.01,;2.67,12.32,;5.33,6.16,;6.87,6.16,;3.79,6.16,;5.33,4.62,;6.67,3.85,;8,4.62,;6.67,2.31,;8,1.54,;8,,;6.67,-.77,;5.33,,;5.33,1.54,;4,2.31,;2.67,1.54,;2.67,,;1.33,-.77,;1.33,-2.31,;,-3.08,;,-4.62,;-1.54,-4.62,;1.54,-4.62,;,-6.16,;;-1.46,-.48,;-2.37,.77,;-1.46,2.02,;,1.54,;1.33,2.31,;6.67,-2.31,;8,-3.08,;8,-4.62,;6.67,-5.39,;6.67,-6.93,;5.33,-7.7,;5.33,-9.24,;4,-10.01,;2.67,-9.24,;1.85,-10.55,;1.13,-9.29,;2.67,-7.7,;4,-6.93,;6.67,-10.01,;8,-9.24,;9.34,-10.01,;9.34,-11.55,;10.67,-12.32,;8,-12.32,;6.67,-11.55,;5.33,-4.62,;5.33,-3.08,;2.67,15.4,;2.67,16.94,)|

Structure