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TargetRAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D]
LigandBDBM238345
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
IC50 6.1±n/a nM
Citation Bae, IHHan, SMKwak, EJAhn, YGSuh, KH Isoquinoline-5-carboxamide derivative having inhibitory activity for protein kinase US Patent US9388165 Publication Date 7/12/2016
More Info.:Get all data from this article,  Assay Method
 
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D]
Name:RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D]
Synonyms:C-RAF (Y340D Y341D) | RAF | RAF proto-oncogene serine/threonine-protein kinase (Y340D/Y341D) | RAF proto-oncogene serine/threonine-protein kinase (c-Raf)(Y340D)(Y341D) | RAF1 | RAF1_HUMAN
Type:Serine/threonine-protein kinase
Mol. Mass.:72984.33
Organism:Homo sapiens (Human)
Description:P04049 Y340D Y341D
Residue:648
Sequence:
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSDDWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM238345
n/a
NameBDBM238345
Synonyms:US9388165, 1
TypeSmall organic molecule
Emp. Form.C25H19F3N4O2
Mol. Mass.464.4392
SMILESCc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1NC(=O)c1cccc2c(N)nccc12
Structure
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