Reaction Details |
| Report a problem with these data |
Target | RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] |
---|
Ligand | BDBM238345 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Inhibition Assay |
---|
IC50 | 6.1±n/a nM |
---|
Citation | Bae, IH; Han, SM; Kwak, EJ; Ahn, YG; Suh, KH Isoquinoline-5-carboxamide derivative having inhibitory activity for protein kinase US Patent US9388165 Publication Date 7/12/2016 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] |
---|
Name: | RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] |
Synonyms: | C-RAF (Y340D Y341D) | RAF | RAF proto-oncogene serine/threonine-protein kinase (Y340D/Y341D) | RAF proto-oncogene serine/threonine-protein kinase (c-Raf)(Y340D)(Y341D) | RAF1 | RAF1_HUMAN |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 72984.33 |
Organism: | Homo sapiens (Human) |
Description: | P04049 Y340D Y341D |
Residue: | 648 |
Sequence: | MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSDDWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
|
|
|
BDBM238345 |
---|
n/a |
---|
Name | BDBM238345 |
Synonyms: | US9388165, 1 |
Type | Small organic molecule |
Emp. Form. | C25H19F3N4O2 |
Mol. Mass. | 464.4392 |
SMILES | Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1NC(=O)c1cccc2c(N)nccc12 |
Structure |
|