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TargetMacrophage colony-stimulating factor 1 receptor (c-Fms)
LigandBDBM238129
Substrate/Competitorn/a
Meas. Tech.Fluorescence Polarization Competition Immunoassay
pH7.5±n/a
Temperature298.15±n/a K
IC50 0.49±n/a nM
Commentsextracted
Citation Illig CRBallentine SKChen JDesjarlais RLMeegalla SKWall MWilson KTomczuk BE Inhibitors of c-fms kinase US Patent  US9394289 Publication Date 7/19/2016
More Info.:Get all data from this article,  Assay Method
 
Macrophage colony-stimulating factor 1 receptor (c-Fms)
Name:Macrophage colony-stimulating factor 1 receptor (c-Fms)
Synonyms:Macrophage colony-stimulating factor 1 receptor | Proto-oncogene c-Fms
Type:Protein
Mol. Mass.:109173.45
Organism:Mus musculus (Mouse)
Description:P09581
Residue:977
Sequence:
MELGPPLVLLLATVWHGQGAPVIEPSGPELVVEPGETVTLRCVSNGSVEWDGPISPYWTL
DPESPGSTLTTRNATFKNTGTYRCTELEDPMAGSTTIHLYVKDPAHSWNLLAQEVTVVEG
QEAVLPCLITDPALKDSVSLMREGGRQVLRKTVYFFSPWRGFIIRKAKVLDSNTYVCKTM
VNGRESTSTGIWLKVNRVHPEPPQIKLEPSKLVRIRGEAAQIVCSATNAEVGFNVILKRG
DTKLEIPLNSDFQDNYYKKVRALSLNAVDFQDAGIYSCVASNDVGTRTATMNFQVVESAY
LNLTSEQSLLQEVSVGDSLILTVHADAYPSIQHYNWTYLGPFFEDQRKLEFITQRAIYRY
TFKLFLNRVKASEAGQYFLMAQNKAGWNNLTFELTLRYPPEVSVTWMPVNGSDVLFCDVS
GYPQPSVTWMECRGHTDRCDEAQALQVWNDTHPEVLSQKPFDKVIIQSQLPIGTLKHNMT
YFCKTHNSVGNSSQYFRAVSLGQSKQLPDESLFTPVVVACMSVMSLLVLLLLLLLYKYKQ
KPKYQVRWKIIERYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAF
GLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVI
TEYCCYGDLLNFLRRKAEAMLGPSLSPGQDSEGDSSYKNIHLEKKYVRRDSGFSSQGVDT
YVEMRPVSTSSSDSFFKQDLDKEASRPLELWDLLHFSSQVAQGMAFLASKNCIHRDVAAR
NVLLTSGHVAKIGDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTVQSDVWSYG
ILLWEIFSLGLNPYPGILVNNKFYKLVKDGYQMAQPVFAPKNIYSIMQSCWDLEPTRRPT
FQQICFLLQEQARLERRDQDYANLPSSGGSSGSDSGGGSSGGSSSEPEEESSSEHLACCE
PGDIAQPLLQPNNYQFC
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  Blast E-value cutoff:
BDBM238129
n/a
NameBDBM238129
Synonyms:US9394289, 25
TypeSmall organic molecule
Emp. Form.C25H30N4O3
Mol. Mass.434.5307
SMILESCC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1(CO)CCOCC1 |c:5|
Structure
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