| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Epidermal growth factor receptor [668-1210] |
|---|
| Ligand | BDBM238272 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Omnia Assay |
|---|
| pH | 7.5±n/a |
|---|
| IC50 | 200±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Lee, K; Niu, D; Baevsky, MF Mutant-selective EGFR inhibitors and uses thereof US Patent US9409887 Publication Date 8/9/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Epidermal growth factor receptor [668-1210] |
|---|
| Name: | Epidermal growth factor receptor [668-1210] |
|---|
| Synonyms: | EGF-R Tyrosine Kinase | EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal growth factor receptor (EGFR) | HER1 | Receptor tyrosine-protein kinase ErbB-1 |
|---|
| Type: | Cytoplasmic region |
|---|
| Mol. Mass.: | 61304.06 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Wildtype EGFR was purchased from Invitrogen. |
|---|
| Residue: | 543 |
|---|
| Sequence: | MRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVY
KGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQ
LITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT
PQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWEL
MTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIE
FSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSP
STSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFL
PVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCV
NSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEF
IGA
|
|
|
|---|
| BDBM238272 |
|---|
| n/a |
|---|
| Name | BDBM238272 |
|---|
| Synonyms: | US9409887, I-3 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H32F3N7O4 |
|---|
| Mol. Mass. | 599.6041 |
|---|
| SMILES | COc1cc(NC2CN(C2)C(=O)OC(C)(C)C)ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
