| Reaction Details |
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 | Report a problem with these data |
| Target | Epidermal growth factor receptor [668-1210] |
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| Ligand | BDBM238274 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Omnia Assay |
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| pH | 7.5±n/a |
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| IC50 | 20±n/a nM |
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| Comments | extracted |
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| Citation |  Lee, K; Niu, D; Baevsky, MF Mutant-selective EGFR inhibitors and uses thereof US Patent US9409887 Publication Date 8/9/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Epidermal growth factor receptor [668-1210] |
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| Name: | Epidermal growth factor receptor [668-1210] |
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| Synonyms: | EGF-R Tyrosine Kinase | EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal growth factor receptor (EGFR) | HER1 | Receptor tyrosine-protein kinase ErbB-1 |
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| Type: | Cytoplasmic region |
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| Mol. Mass.: | 61304.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Wildtype EGFR was purchased from Invitrogen. |
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| Residue: | 543 |
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| Sequence: | MRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVY
KGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQ
LITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT
PQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWEL
MTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIE
FSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSP
STSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFL
PVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCV
NSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEF
IGA
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| BDBM238274 |
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| n/a |
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| Name | BDBM238274 |
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| Synonyms: | US9409887, I-5 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H25F3N6O2 |
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| Mol. Mass. | 486.4895 |
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| SMILES | COc1cc(NC(C)C)ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F |
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| Structure | 
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