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TargetE3 ubiquitin-protein ligase SMURF1 [420-757]
LigandBDBM239098
Substrate/Competitorn/a
Meas. Tech.Biochemical Assay
Temperature298.15±n/a K
IC50 33±n/a nM
Commentsextracted
Citation Bala, KJBrearley, ADale, JEdwards, AAhmed, MPorter, DPulz, RARooney, LASandham, DAShaw, DSmith, NTaylor, JLTaylor, RJTroxler, TJWrigglesworth, J Carboxamide derivatives US Patent US9403810 Publication Date 8/2/2016
More Info.:Get all data from this article,  Assay Method
 
E3 ubiquitin-protein ligase SMURF1 [420-757]
Name:E3 ubiquitin-protein ligase SMURF1 [420-757]
Synonyms:HECT-type E3 ubiquitin transferase SMURF1 | KIAA1625 | SMUF1_HUMAN | SMURF1
Type:Enzyme
Mol. Mass.:39188.96
Organism:Homo sapiens (Human)
Description:HECTdomain amino acid 420-757
Residue:338
Sequence:
RPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDS
SINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSL
VWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRG
IEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIV
RWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNL
PKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
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  Blast E-value cutoff:
BDBM239098
n/a
NameBDBM239098
Synonyms:US10195181, Example 1.7 | US9403810, 1.7
TypeSmall organic molecule
Emp. Form.C23H29F3N4O3
Mol. Mass.466.4966
SMILESCc1c(noc1C1=CCC(CC1)C(F)(F)F)C(=O)Nc1c(C)n(C)n(C2CCCCC2)c1=O |t:7|
Structure
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