Reaction Details |
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Target | E3 ubiquitin-protein ligase Mdm2 [2-188]/Protein Mdm4 [2-185] |
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Ligand | BDBM238902 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Time Resolved Fluorescence Energy Transfer (TR-FRET) Assay |
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Temperature | 298.15±n/a K |
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IC50 | 16690±n/a nM |
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Comments | extracted |
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Citation | Furet, P; Guagnano, V; Holzer, P; Kallen, J; Mah, R; Masuya, K; Schlapbach, A; Vaupel, A Substituted purinone compounds US Patent US9403827 Publication Date 8/2/2016 |
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More Info.: | Get all data from this article, Assay Method |
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E3 ubiquitin-protein ligase Mdm2 [2-188]/Protein Mdm4 [2-185] |
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Name: | E3 ubiquitin-protein ligase Mdm2 [2-188]/Protein Mdm4 [2-185] |
Synonyms: | p53-MDM4 |
Type: | Protein |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | E3 ubiquitin-protein ligase Mdm2 [2-188] |
Synonyms: | E3 ubiquitin-protein ligase Mdm2 | MDM2 | MDM2_HUMAN |
Type: | Protein |
Mol. Mass.: | 21187.98 |
Organism: | Homo sapiens (Human) |
Description: | aa 2-188 |
Residue: | 187 |
Sequence: | CNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYI
MTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTS
VSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQR
KRHKSDS
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Component 2 |
Name: | Protein Mdm4 [2-185] |
Synonyms: | E3 ubiquitin-protein ligase Mdm4 | MDM4 | MDM4_HUMAN | MDMX | p53-binding protein Mdm4 |
Type: | Protein |
Mol. Mass.: | 20438.64 |
Organism: | Homo sapiens (Human) |
Description: | aa 2-185 |
Residue: | 184 |
Sequence: | TSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIM
VKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLA
LAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQD
ETSR
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BDBM238902 |
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n/a |
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Name | BDBM238902 |
Synonyms: | US9403827, 4 |
Type | Small organic molecule |
Emp. Form. | C28H27Cl2N5O2 |
Mol. Mass. | 536.452 |
SMILES | COc1ccncc1-c1nc2NC(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C |
Structure |
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