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TargetE3 ubiquitin-protein ligase Mdm2 [2-188]/Protein Mdm4 [2-185]
LigandBDBM238902
Substrate/Competitorn/a
Meas. Tech.Time Resolved Fluorescence Energy Transfer (TR-FRET) Assay
Temperature298.15±n/a K
IC50 16690±n/a nM
Commentsextracted
Citation Furet, PGuagnano, VHolzer, PKallen, JMah, RMasuya, KSchlapbach, AVaupel, A Substituted purinone compounds US Patent US9403827 Publication Date 8/2/2016
More Info.:Get all data from this article,  Assay Method
 
E3 ubiquitin-protein ligase Mdm2 [2-188]/Protein Mdm4 [2-185]
Name:E3 ubiquitin-protein ligase Mdm2 [2-188]/Protein Mdm4 [2-185]
Synonyms:p53-MDM4
Type:Protein
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:E3 ubiquitin-protein ligase Mdm2 [2-188]
Synonyms:E3 ubiquitin-protein ligase Mdm2 | MDM2 | MDM2_HUMAN
Type:Protein
Mol. Mass.:21187.98
Organism:Homo sapiens (Human)
Description:aa 2-188
Residue:187
Sequence:
CNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYI
MTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTS
VSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQR
KRHKSDS
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Component 2
Name:Protein Mdm4 [2-185]
Synonyms:E3 ubiquitin-protein ligase Mdm4 | MDM4 | MDM4_HUMAN | MDMX | p53-binding protein Mdm4
Type:Protein
Mol. Mass.:20438.64
Organism:Homo sapiens (Human)
Description:aa 2-185
Residue:184
Sequence:
TSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIM
VKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLA
LAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQD
ETSR
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BDBM238902
n/a
NameBDBM238902
Synonyms:US9403827, 4
TypeSmall organic molecule
Emp. Form.C28H27Cl2N5O2
Mol. Mass.536.452
SMILESCOc1ccncc1-c1nc2NC(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C
Structure
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