Reaction Details |
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Target | Histone deacetylase 4 |
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Ligand | BDBM293892 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Biochemical HDAC-4 Assay |
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IC50 | 20.0±n/a nM |
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Citation | Dominguez, C; Muñoz-Sanjuán, I; Maillard, M; Luckhurst, CA; Jarvis, RE; Bürli, RW; Allen, DR; Haughan, AF; Breccia, P; Vater, HD; Stott, AJ; Penrose, SD; Wall, M; Saville-Stones, EA; Wishart, G; Hughes, SJ Histone deacetylase inhibitors and compositions and methods of use thereof US Patent US10106535 Publication Date 10/23/2018 |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 4 |
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Name: | Histone deacetylase 4 |
Synonyms: | Cereblon/Histone deacetylase 4 | HD4 | HDAC4 | HDAC4_HUMAN | Histone acetylase 4(HDAC4) | Human HDAC4 | KIAA0288 |
Type: | Enzyme |
Mol. Mass.: | 119049.39 |
Organism: | Homo sapiens (Human) |
Description: | P56524 |
Residue: | 1084 |
Sequence: | MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLP
VAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLA
MKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVL
NKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFP
LRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGP
SSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPA
TGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLL
EQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHL
VIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPY
LDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQ
RIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDT
LMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT
LLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVE
LVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWD
VHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDP
PMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQL
MGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKV
MEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEE
EPPL
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BDBM293892 |
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n/a |
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Name | BDBM293892 |
Synonyms: | (S)-3-(1-(Difluoromethyl)- 1H-pyrazol-4-yl)-1-(3- fluoro-2-methylphenyl)- N-hydroxycyclopent-2- enecarboxamide | US10106535, Example 18 | US9617259, 18 |
Type | Small organic molecule |
Emp. Form. | C17H16F3N3O2 |
Mol. Mass. | 351.323 |
SMILES | Cc1c(F)cccc1[C@@]1(CCC(=C1)c1cnn(c1)C(F)F)C(=O)NO |r,c:12| |
Structure |
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