| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Beta-carbonic anhydrase 1 |
|---|
| Ligand | BDBM11611 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | CA Inhibition Assay |
|---|
| pH | 8.3±0 |
|---|
| Temperature | 298.15±0 K |
|---|
| Ki | 4.1e+2±n/a nM |
|---|
| Citation |  Maresca, A; Scozzafava, A; Vullo, D; Supuran, CT Dihalogenated sulfanilamides and benzolamides are effective inhibitors of the three ß-class carbonic anhydrases from Mycobacterium tuberculosis. J Enzyme Inhib Med Chem28:384-7 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Beta-carbonic anhydrase 1 |
|---|
| Name: | Beta-carbonic anhydrase 1 |
|---|
| Synonyms: | β-Carbonic anhydrase 1 (CA 1) | Carbonic Anhydrase (mtCA 1) | MTCA1_MYCTU | Uncharacterized protein Rv1284/MT1322 | canA | mtcA1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 18186.06 |
|---|
| Organism: | Mycobacterium tuberculosis |
|---|
| Description: | The recombinant GST-mtCA1 construct was cloned, expressed, and further purified from E. coli. The purified protein was used in inhibition assays. |
|---|
| Residue: | 163 |
|---|
| Sequence: | MTVTDDYLANNVDYASGFKGPLPMPPSKHIAIVACMDARLDVYRMLGIKEGEAHVIRNAG
CVVTDDVIRSLAISQRLLGTREIILLHHTDCGMLTFTDDDFKRAIQDETGIRPTWSPESY
PDAVEDVRQSLRRIEVNPFVTKHTSLRGFVFDVATGKLNEVTP
|
|
|
|---|
| BDBM11611 |
|---|
| n/a |
|---|
| Name | BDBM11611 |
|---|
| Synonyms: | β-CA inhibitor, 10 | 4-Amino-3,5-dibromobenzenesulfonamide | 4-amino-3,5-dibromobenzene-1-sulfonamide | CHEMBL306195 | halogenosulfanilamide deriv. 12 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C6H6Br2N2O2S |
|---|
| Mol. Mass. | 329.997 |
|---|
| SMILES | Nc1c(Br)cc(cc1Br)S(N)(=O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
